TY - JOUR
T1 - Neurocognitive performance in children aged 9-12 years who present putative antecedents of schizophrenia
AU - Cullen, Alexis
AU - Dickson, Hannah
AU - West, Sophie A.
AU - Morris, Robin G.
AU - Mould, Glenn L.
AU - Hodgins, Sheilagh
AU - Murray, Robin M.
AU - Laurens, Kristin R.
PY - 2010/8
Y1 - 2010/8
N2 - Background: We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia.
Methods: Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition.
Results: Relative to TD children, the ASz group showed poorer performance on all neurocognitive tests (mean Cohen's d effect size = 0.52). In linear regression analyses, group status (ASz vs. TD) significantly predicted scores on the general intelligence, verbal memory, working memory, and EF-inhibition domains (p
AB - Background: We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia.
Methods: Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition.
Results: Relative to TD children, the ASz group showed poorer performance on all neurocognitive tests (mean Cohen's d effect size = 0.52). In linear regression analyses, group status (ASz vs. TD) significantly predicted scores on the general intelligence, verbal memory, working memory, and EF-inhibition domains (p
U2 - 10.1016/j.schres.2010.05.034
DO - 10.1016/j.schres.2010.05.034
M3 - Article
SN - 1573-2509
VL - 121
SP - 15
EP - 23
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -