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Neurodevelopmental origins of self-limiting rolandic epilepsy: Systematic review of MR imaging studies

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)310-322
Number of pages13
JournalEpilepsia Open
Volume6
Issue number2
DOIs
Accepted/In press2021
PublishedJun 2021

Bibliographical note

Funding Information: This work was supported by the European Union Program of the Seventh Framework: Development of Strategies for Innovative Research to Improve Diagnosis, Prevention and Treatment in Children With Difficult to Treat Epilepsy, “DESIRE” (602531, (DKP.)); UK Medical Research Council, Centre for Neurodevelopmental Disorders (MR/N026063/1 (DKP, MPR.)); UK Medical Research Council, Programme grant (MR/K013998/1, MRP.); a Waterloo Foundation Project Grants (164‐3020 (DKP.) and 164‐2358 (DKP/SDWS)); the Charles Sykes Epilepsy Research Trust (DKP.); and NIHR Specialist Biomedical Research Centre for Mental Health of South London and Maudsley National Health Service Foundation Trust (DKP, MPR). Funding Information: This work was supported by the European Union Program of the Seventh Framework: Development of Strategies for Innovative Research to Improve Diagnosis, Prevention and Treatment in Children With Difficult to Treat Epilepsy, ?DESIRE? (602531, (DKP.)); UK Medical Research Council, Centre for Neurodevelopmental Disorders (MR/N026063/1 (DKP, MPR.)); UK Medical Research Council, Programme grant (MR/K013998/1, MRP.); a Waterloo Foundation Project Grants (164-3020 (DKP.) and 164-2358 (DKP/SDWS)); the Charles Sykes Epilepsy Research Trust (DKP.); and NIHR Specialist Biomedical Research Centre for Mental Health of South London and Maudsley National Health Service Foundation Trust (DKP, MPR). Publisher Copyright: © 2021 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Objective: Recent neuroimaging studies have revealed differences in cortical and white matter brain structure in children with self-limiting rolandic epilepsy (RE). Despite this, reproducibility of the findings has been difficult, and there is no consensus about where and when structural differences are most apparent. We performed a systematic review of quantitative neuroimaging studies in children with RE to explore these questions. Methods: Using PRISMA guidelines, we used a multilayered search strategy to identify neuroimaging studies in RE. Publications were included if they were quantitative and derived from controlled group studies and passed a quality assessment. Findings of the studies were presented and stratified by duration of epilepsy and age of participants. Results: We identified six gray matter studies and five white matter studies. Consistent findings were found inside and outside the central sulcus, predominantly within the bilateral frontal and parietal lobes, striatal structures, such as the putamen and white matter, mainly involving the left superior longitudinal fasciculus and connections between the left pre- and postcentral gyrus. Stratification of the T1 studies by age found that cortical thickness differences varied between the under and over 10 year olds. Furthermore, the longer the duration of epilepsy, the less likely differences were detected. In white matter studies, there was a reduction in differences with increased age and duration of epilepsy. Significance: These findings would suggest that the development of regions of the cortex in children with RE is abnormal. These regions are more widespread than the suspected seizure onset zone. Moreover, the findings would suggest that these differences are evidence of neurodevelopmental delay rather than apparent “damage” from the epilepsy.

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