Neurodevelopmental roles and the serotonin hypothesis of autism spectrum disorder

Eileen Daly; Mark D. Tricklebank; Robert Wichers

doi:10.1016/B978-0-12-813323-1.00002-5

Neurodevelopmental roles and the serotonin hypothesis of autism spectrum disorder

Eileen Daly, Mark D. Tricklebank, Robert Wichers

Neuroimaging

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

10 Citations (Scopus)

Abstract

In addition to its role as a neurotransmitter, the indolamine serotonin [5-hydroxytryptamine (5-HT)] also acts as a signaling molecule for 5-HT neuron growth in the developing brain. Detected in the first trimester of the human central nervous system, 5-HT acts as a trophic factor-a regulator of neuronal growth, differentiation, migration, and survival. The trophic role of 5-HT occurs long before synapse formation and the need for 5-HT to perform as a neurotransmitter. The trophic role of 5-HT continues throughout prenatal and early postnatal development. Disruption, even transient deviations, of the 5-HT system during development, can lead to permanent alterations in brain function and behavior. One neurodevelopmental condition with growing evidence of 5-HT involvement is autism spectrum disorder.

Original language	English
Title of host publication	The Serotonin System
Subtitle of host publication	History, Neuropharmacology, and Pathology
Publisher	Elsevier
Pages	23-44
Number of pages	22
ISBN (Electronic)	9780128133231
ISBN (Print)	9780128133248
DOIs	https://doi.org/10.1016/B978-0-12-813323-1.00002-5
Publication status	Published - 1 Jan 2019

Keywords

Autism
Neurodevelopment
Neuronal differentiation
Neuronal growth
Neuronal migration
Neurons

Access to Document

10.1016/B978-0-12-813323-1.00002-5

Cite this

@inbook{05ba9fadd6f54be1b489ac426070c1cf,

title = "Neurodevelopmental roles and the serotonin hypothesis of autism spectrum disorder",

abstract = "In addition to its role as a neurotransmitter, the indolamine serotonin [5-hydroxytryptamine (5-HT)] also acts as a signaling molecule for 5-HT neuron growth in the developing brain. Detected in the first trimester of the human central nervous system, 5-HT acts as a trophic factor-a regulator of neuronal growth, differentiation, migration, and survival. The trophic role of 5-HT occurs long before synapse formation and the need for 5-HT to perform as a neurotransmitter. The trophic role of 5-HT continues throughout prenatal and early postnatal development. Disruption, even transient deviations, of the 5-HT system during development, can lead to permanent alterations in brain function and behavior. One neurodevelopmental condition with growing evidence of 5-HT involvement is autism spectrum disorder.",

keywords = "Autism, Neurodevelopment, Neuronal differentiation, Neuronal growth, Neuronal migration, Neurons",

author = "Eileen Daly and Tricklebank, {Mark D.} and Robert Wichers",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-813323-1.00002-5",

language = "English",

isbn = "9780128133248",

pages = "23--44",

booktitle = "The Serotonin System",

publisher = "Elsevier",

address = "Netherlands",

}

TY - CHAP

T1 - Neurodevelopmental roles and the serotonin hypothesis of autism spectrum disorder

AU - Daly, Eileen

AU - Tricklebank, Mark D.

AU - Wichers, Robert

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In addition to its role as a neurotransmitter, the indolamine serotonin [5-hydroxytryptamine (5-HT)] also acts as a signaling molecule for 5-HT neuron growth in the developing brain. Detected in the first trimester of the human central nervous system, 5-HT acts as a trophic factor-a regulator of neuronal growth, differentiation, migration, and survival. The trophic role of 5-HT occurs long before synapse formation and the need for 5-HT to perform as a neurotransmitter. The trophic role of 5-HT continues throughout prenatal and early postnatal development. Disruption, even transient deviations, of the 5-HT system during development, can lead to permanent alterations in brain function and behavior. One neurodevelopmental condition with growing evidence of 5-HT involvement is autism spectrum disorder.

AB - In addition to its role as a neurotransmitter, the indolamine serotonin [5-hydroxytryptamine (5-HT)] also acts as a signaling molecule for 5-HT neuron growth in the developing brain. Detected in the first trimester of the human central nervous system, 5-HT acts as a trophic factor-a regulator of neuronal growth, differentiation, migration, and survival. The trophic role of 5-HT occurs long before synapse formation and the need for 5-HT to perform as a neurotransmitter. The trophic role of 5-HT continues throughout prenatal and early postnatal development. Disruption, even transient deviations, of the 5-HT system during development, can lead to permanent alterations in brain function and behavior. One neurodevelopmental condition with growing evidence of 5-HT involvement is autism spectrum disorder.

KW - Autism

KW - Neurodevelopment

KW - Neuronal differentiation

KW - Neuronal growth

KW - Neuronal migration

KW - Neurons

UR - http://www.scopus.com/inward/record.url?scp=85081928647&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-813323-1.00002-5

DO - 10.1016/B978-0-12-813323-1.00002-5

M3 - Chapter

SN - 9780128133248

SP - 23

EP - 44

BT - The Serotonin System

PB - Elsevier

ER -

Neurodevelopmental roles and the serotonin hypothesis of autism spectrum disorder

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this