Neurofilaments and neurological disease

A Al-Chalabi; C C J Miller

doi:10.1002/bies.10251

Neurofilaments and neurological disease

A Al-Chalabi, C C J Miller

Basic and Clinical Neuroscience

Research output: Contribution to journal › Literature review › peer-review

164 Citations (Scopus)

Abstract

Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by posttranslational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments.

Original language	English
Pages (from-to)	346 - 355
Number of pages	10
Journal	Bioessays
Volume	25
Issue number	4
DOIs	https://doi.org/10.1002/bies.10251
Publication status	Published - 1 Apr 2003

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AB - Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by posttranslational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments.

U2 - 10.1002/bies.10251

DO - 10.1002/bies.10251

M3 - Literature review

SN - 1521-1878

VL - 25

SP - 346

EP - 355

JO - Bioessays

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ER -

Neurofilaments and neurological disease

Abstract

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