J. M. Stone*, L. S. Pilowsky

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The discovery of chlorpromazine as an antipsychotic drug (neuroleptic) in 1952 heralded the start of a new era in the management of patients with the schizophrenia. It was not until the mid-1970s that the relationship between high affinity for dopamine receptors and clinical potency of antipsychotic drugs emerged. This led to the hypothesis that schizophrenia was caused by excess dopamine in the striatum. Later refinements to the theory, driven by the finding that some effective antipsychotic drugs, such as clozapine, showed low striatal but high temporal cortex binding, suggested that dopamine transmission in extrastriatal regions might be more relevant.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages7
ISBN (Print)9780080450469
Publication statusPublished - 1 Dec 2010


  • Antipsychotic
  • Caudate
  • Chlorpromazine
  • Clozapine
  • Dopamine
  • Drug treatment
  • Neuroleptic
  • Psychosis
  • Putamen
  • Schizophrenia
  • Striatum
  • Temporal cortex


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