We examined the relationship between neurological function at illness onset assessed with the Neurological Evaluation Scale, and subsequent illness course in 233 patients from AESOP-10, a 10-year follow up study of a population-based cohort of individuals recruited at the time of their first episode of psychosis in the UK. In 56 of these patients we also explored changes in neurological function over time. We included a group of 172 individuals without psychosis as controls.
After ten years, 147 (63%) patients had developed a Non-Remitting course of illness, and 86 (37%) a Remitting course. Already at first presentation, patients who developed a Non-Remitting course had significantly more Primary, Motor Coordination, and Total signs than both Remitting patients and healthy controls. While Motor Coordination signs did not change over time, rates of Primary, Sensory Integration and Total signs increased, independently of illness course type.
These findings suggest that motor coordination problems could be a useful early, quick and easily detectable marker of subsequent clinical outcome. With other motor abnormalities, a measure of motor incoordination could contribute to the identification of the most vulnerable individuals, who could benefit from targeted and more assertive treatment approaches.
|Publication status||Accepted/In press - 2020|
- Neurological signs,
- first episode psychosis
- clinical outcome