TY - JOUR
T1 - Neuromodulation with Transcranial Magnetic Stimulation in Epilepsia Partialis Continua
T2 - Scoping review and clinical experience
AU - Velasco-Mérida, Matilde
AU - Lázaro, Marian
AU - Duncan, John S
AU - Alarcon, Gonzalo
AU - Stavropoulos, Ioannis
AU - Valentín, Antonio
N1 - Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2024/12
Y1 - 2024/12
N2 - INTRODUCTION: Epilepsia Partialis Continua (EPC) is a challenging condition in which repetitive transcranial magnetic stimulation (rTMS) can induce a neuromodulation effect of potential diagnostic and therapeutic value.METHODS: A comprehensive literature search was conducted using Pubmed and Web of Science databases to identify cases of EPC who underwent rTMS, including children and adults. Additionally, we present two patients from our centre who underwent rTMS at a low frequency (0.5 Hz) with simultaneous EEG recording with the aim of assessing potential improvement in seizure frequency and severity.RESULTS: Eight articles were selected comprising 16 patients (15 with EPC and one with continuous myoclonia). In three of these patients, no clinical or EEG changes were noted; the remaining cases showed transitory clinical improvements. We report two patients with EPC, in whom low frequency rTMS was associated with transient reduction in frequency and severity of seizures and improvements in hand function and dexterity. In one of these cases, rTMS suggested a potential target for intracranial recordings, subacute cortical stimulation and localised resection.CONCLUSION: In selected patients with EPC, rTMS can be used as a potential diagnostic and therapeutic tool.
AB - INTRODUCTION: Epilepsia Partialis Continua (EPC) is a challenging condition in which repetitive transcranial magnetic stimulation (rTMS) can induce a neuromodulation effect of potential diagnostic and therapeutic value.METHODS: A comprehensive literature search was conducted using Pubmed and Web of Science databases to identify cases of EPC who underwent rTMS, including children and adults. Additionally, we present two patients from our centre who underwent rTMS at a low frequency (0.5 Hz) with simultaneous EEG recording with the aim of assessing potential improvement in seizure frequency and severity.RESULTS: Eight articles were selected comprising 16 patients (15 with EPC and one with continuous myoclonia). In three of these patients, no clinical or EEG changes were noted; the remaining cases showed transitory clinical improvements. We report two patients with EPC, in whom low frequency rTMS was associated with transient reduction in frequency and severity of seizures and improvements in hand function and dexterity. In one of these cases, rTMS suggested a potential target for intracranial recordings, subacute cortical stimulation and localised resection.CONCLUSION: In selected patients with EPC, rTMS can be used as a potential diagnostic and therapeutic tool.
KW - Humans
KW - Electroencephalography
KW - Epilepsia Partialis Continua/therapy
KW - Transcranial Magnetic Stimulation/methods
U2 - 10.1016/j.seizure.2024.10.018
DO - 10.1016/j.seizure.2024.10.018
M3 - Article
C2 - 39522494
SN - 1059-1311
VL - 123
SP - 74
EP - 81
JO - Seizure
JF - Seizure
ER -