Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation

Louise Kay; Lawrence Humphreys; Britta J. Eickholt; Juan Burrone

doi:10.1038/nn.2826

Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation

Louise Kay, Lawrence Humphreys, Britta J. Eickholt, Juan Burrone

Developmental Neurobiology

King's College London

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses only gradually become functionally matched and that this process is dependent on ongoing electrical activity.

Original language	English
Pages (from-to)	688 - 690
Number of pages	3
Journal	Nature Neuroscience
Volume	14
Issue number	6
DOIs	https://doi.org/10.1038/nn.2826
Publication status	Published - Jun 2011

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abstract = "The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses only gradually become functionally matched and that this process is dependent on ongoing electrical activity.",

author = "Louise Kay and Lawrence Humphreys and Eickholt, {Britta J.} and Juan Burrone",

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Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation

Abstract

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