Neurons derive from the more apical daughter in asymmetric divisions in the zebrafish neural tube

Paula Ale De Paiva Alexandre, Alexander M. Reugels, David Barker, Eric Blanc, Jonathan D. W. Clarke

Research output: Contribution to journalArticlepeer-review

118 Citations (Scopus)

Abstract

In the developing CNS, asymmetric cell division is critical for maintaining the balanced production of differentiating neurons while renewing the population of neural progenitors. In invertebrates, this process depends on asymmetric inheritance of fate determinants during progenitor divisions. A similar mechanism is widely believed to underlie asymmetrically fated divisions in vertebrates, but compelling evidence for this is missing. We used live imaging of individual progenitors in the intact zebrafish embryo CNS to test this hypothesis. We found that asymmetric inheritance of a subcellular domain is strongly correlated with asymmetric daughter fates and our results reveal an unexpected feature of this process. The daughter cell destined to become a neuron was derived from the more apical of the two daughters, whereas the more basal daughter inherited the basal process and replenished the apical progenitor pool.
Original languageEnglish
Pages (from-to)673 - 679
Number of pages7
JournalNature Neuroscience
Volume13
Issue number6
Early online date9 May 2010
DOIs
Publication statusPublished - Jun 2010

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