@inbook{d5d9f3e059d544ca8dd83f1d08c17a57,
title = "Neuropathic Tissue Responds Preferentially to Stimulation by Intense Focused Ultrasound",
abstract = "We tested the hypothesis that neuropathic tissue is more sensitive to stimulation by intense focused ultrasound (iFU) than control tissue. We created a diffusely neuropathic paw in rats via partial ligation of the sciatic nerve, whose sensitivity to iFU stimulation we compared with sham-surgery and normal control paws. We then applied increasing amounts of iFU (individual 0.2 s pulses at 1.15 MHz) to the rats' paws, assaying for their reliable withdrawal from that stimulation. Neuropathic rats preferentially withdrew their injured paw from iFU at smaller values of iFU intensity (84.2 W/cm2± 25.5) than did sham surgery (97.7 W/cm2± 11.9) and normal control (> 223 W/cm2) animals, with greater sensitivity and specificity (85% for neuropathic rats and 50% each of sham surgery and normal control rats). These results directly support our hypothesis as well as Gavrilov's idea that doctors may some day use iFU stimulation to diagnose patients with neuropathies. {\textcopyright} 2013 World Federation for Ultrasound in Medicine & Biology.",
keywords = "Intense focused ultrasound, Neuropathy, Pain, Pain diagnosis",
author = "Tych, {Rowen E.} and Michael Gofeld and Jarvik, {Jeffrey G.} and Michel Kliot and Loeser, {John D.} and McClintic, {Abbi M.} and Ollos, {Ryan J.} and Pederson, {Kristin D.} and Sparks, {Rachel E.} and Terman, {Gregory W.} and Mourad, {Pierre D.}",
year = "2013",
doi = "10.1016/j.ultrasmedbio.2012.08.012",
language = "English",
isbn = "3300000106",
series = "Ultrasound in Medicine and Biology",
publisher = "Elsevier USA",
pages = "111--116",
booktitle = "Ultrasound in Medicine and Biology",
address = "United States",
}