Neuropathological correlates of neuropsychiatric symptoms in dementia

Lucy L. Gibson*, Lea T. Grinberg, Dominic ffytche, Renata E.P. Leite, Roberta D. Rodriguez, Renata E.L. Ferretti-Rebustini, Carlos A. Pasqualucci, Ricardo Nitrini, Wilson Jacob-Filho, Dag Aarsland, Claudia K. Suemoto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)
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Introduction: Neuropsychiatric symptoms (NPS) are common in Lewy body disease (LBD), but their etiology is poorly understood. Methods: In a population-based post mortem study neuropathological data was collected for Lewy body (LB) neuropathology, neurofibrillary tangles (NFT), amyloid beta burden, TDP-43, lacunar infarcts, cerebral amyloid angiopathy (CAA), and hyaline atherosclerosis. Post mortem interviews collected systematic information regarding NPS and cognitive status. A total of 1038 cases were included: no pathology (NP; n = 761), Alzheimer's disease (AD; n = 189), LBD (n = 60), and AD+LBD (n = 28). Results: Hallucinations were associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms in the Neuropsychiatric Inventory. Cases with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms but a multiplicative interaction between these pathologies was not significant. Discussion: LB and AD pathology contribute differentially to NPS likely with an additive process contributing to the increased burden of NPS.

Original languageEnglish
Pages (from-to)1372-1382
Number of pages11
JournalAlzheimer's and Dementia
Issue number4
Publication statusPublished - Apr 2023


  • Lewy body disease
  • neuropathology
  • neuropsychiatric symptoms


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