Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide

TY - JOUR

T1 - Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide

AU - Cikes, Domagoj

AU - Atanes, Patricio

AU - Cronin, Shane J.F.

AU - Hagelkrüys, Astrid

AU - Huang, Guo Cai

AU - Persaud, Shanta J.

AU - Penninger, Josef M.

N1 - Funding Information: We would like to thank all members of our laboratories for helpful discussions. We are grateful to Vienna Biocenter Core Facilities: Transgenic unit, Mouse Phenotyping unit and Comparative medicine unit for their service. We are grateful to the International Mouse Phenotyping Consortium for sharing their NmB LacZ reporter mouse data with us. J.M.P. is supported by IMBA, Wittgenstein award, the T. von Zastrow foundation. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Neuromedin B (NMB) is a member of the neuromedin family of neuropeptides with a high level of region-specific expression in the brain. Several GWAS studies on non-obese and obese patients suggested that polymorphisms in NMB predispose to obesity by affecting appetite control and feeding preference. Furthermore, several studies proposed that NMB can act as an insulin releasing peptide. Since the functional study has never been done, the in vivo role of NMB as modulator of weight gain or glucose metabolism remains unclear. Here, we generated Nmb conditional mice and nervous system deficient NmB mice. We then performed olfactory and food preference analysis, as well as metabolic analysis under standard and high fat diet. Additionally, in direct islet studies we evaluated the role of NMB on basal and glucose-stimulated insulin secretion in mouse and humans.

AB - Neuromedin B (NMB) is a member of the neuromedin family of neuropeptides with a high level of region-specific expression in the brain. Several GWAS studies on non-obese and obese patients suggested that polymorphisms in NMB predispose to obesity by affecting appetite control and feeding preference. Furthermore, several studies proposed that NMB can act as an insulin releasing peptide. Since the functional study has never been done, the in vivo role of NMB as modulator of weight gain or glucose metabolism remains unclear. Here, we generated Nmb conditional mice and nervous system deficient NmB mice. We then performed olfactory and food preference analysis, as well as metabolic analysis under standard and high fat diet. Additionally, in direct islet studies we evaluated the role of NMB on basal and glucose-stimulated insulin secretion in mouse and humans.

UR - http://www.scopus.com/inward/record.url?scp=85131486344&partnerID=8YFLogxK

U2 - 10.1038/s41598-022-13060-0

DO - 10.1038/s41598-022-13060-0

M3 - Article

C2 - 35672347

AN - SCOPUS:85131486344

SN - 2045-2322

VL - 12

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 9383

ER -