Neurophysiological Alterations in the Prepsychotic Phases

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6 Citations (Scopus)

Abstract

Electroencephalography and Magnetoencephalography have provided valuable information about the brain functioning in psychosis. In the last few years, authors have demonstrated that there are neurophysiological alterations already in the prodromal period, before the development of psychosis. This makes them promising tools for predicting a future transition to psychosis. In this paper we review the latest studies using event-related potentials (ERP) in subjects clinically at high-risk of developing psychosis. We particularly focus in the P300, Mismatch-Negativity (MMN) and P50 paradigms, discussing the main findings, but also the limitations and challenges in electrophysiological studies in this population.

Original languageEnglish
Article numberN/A
Pages (from-to)479-485
Number of pages7
JournalCurrent Pharmaceutical Design
Volume18
Issue number4
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Prodrome
  • psychosis
  • EEG
  • ERP
  • EVENT-RELATED POTENTIALS
  • SCHIZOTYPAL PERSONALITY-DISORDER
  • PSYCHOTIC BIPOLAR DISORDER
  • MISMATCH NEGATIVITY MMN
  • RISK MENTAL STATE
  • ULTRA-HIGH-RISK
  • P300 AMPLITUDE
  • AUDITORY P300
  • P50 SUPPRESSION
  • SCHIZOPHRENIA

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