@article{844ed168a7804db4901e1f3bdca9b549,
title = "Neuropsychological and clinical findings of Cognitive Remediation Therapy feasibility randomised controlled trial in young people with anorexia nervosa",
abstract = "Objective: Randomised controlled trial (RCT) in adults with anorexia nervosa (AN) showed that Cognitive Remediation Therapy (CRT) enhances cognitive flexibility, abstract thinking and quality-of-life. Despite inconsistent findings, CRT has the potential as an adjunct treatment for young people (YP) with AN. A feasibility RCT was conducted in an inpatient setting. The study will also consider the effect of CRT in YP with AN and autistic symptoms. Methods: Participants were randomly allocated to the Immediate or Delayed condition to receive individual CRT sessions, in addition to standard treatment. A repeated measures design was conducted. Results: Eighty participants were recruited. The neuropsychological measures were feasible for evaluating individual CRT in YP. Significant improvements in set-shifting and central coherence were found, with no main effect between immediate and delayed condition. Significant interactions were found between the condition, and autism spectrum condition (ASC) and No-ASC subgroup, with significant positive impact of CRT on set-shifting in the No-ASC subgroup. There was some evidence that for the No-ASC subgroup, CRT was more effective if delivered at the start of the treatment; and for the ASC subgroup, that CRT was more effective if delivered at the later stage of treatment. Conclusions: These findings suggest that the overall positive effect of CRT in set-shifting and central coherence alongside standard treatment. They also indicate the importance of screening for the presence of ASC which could require tailored CRT.",
keywords = "anorexia nervosa, ASC, CRT, feasibility RCT, young people",
author = "Lucia Giombini and Sophie Nesbitt and Rutendo Kusosa and Cleo Fabian and Teo Sharia and Abigail Easter and Kate Tchanturia",
note = "Funding Information: Dr. Giombini was supported by Elysium Healthcare. Dr. Easter, King's College London, was supported by the National Institute for Health Research (NIHR) Applied Research Collaboration South London (NIHR ARC South London) at King's College Hospital NHS Foundation Trust. Professor Tchanturia was supported from MRC‐MRF Fund (MR/S020381/1; Biomarkers for Anorexia Nervosa and autism spectrum Disorders‐longitudinal study). The funders played no role in the design, analysis or preparation of the manuscript for the present study. The views expressed are those of the authors and not those of NIHR, or the Department of Health and Social Care, King's College London and Elysium Healthcare. The authors would like to thank all the young people, their carers and staff at Rhodes Wood Hospital. Funding Information: Dr. Giombini was supported by Elysium Healthcare. Dr. Easter, King's College London, was supported by the National Institute for Health Research (NIHR) Applied Research Collaboration South London (NIHR ARC South London) at King's College Hospital NHS Foundation Trust. Professor Tchanturia was supported from MRC-MRF Fund (MR/S020381/1; Biomarkers for Anorexia Nervosa and autism spectrum Disorders-longitudinal study). The funders played no role in the design, analysis or preparation of the manuscript for the present study. The views expressed are those of the authors and not those of NIHR, or the Department of Health and Social Care, King's College London and Elysium Healthcare. The authors would like to thank all the young people, their carers and staff at Rhodes Wood Hospital. Publisher Copyright: {\textcopyright} 2021 Eating Disorders Association and John Wiley & Sons Ltd.",
year = "2022",
month = jan,
doi = "10.1002/erv.2874",
language = "English",
volume = "30",
pages = "50--60",
journal = "European Eating Disorders Review",
issn = "1072-4133",
number = "1",
}