Neuropsychological functioning in first-episode psychosis - evidence of specific deficits

E M Riley; D McGovern; D Mockler; V C K Doku; S OCeallaigh; D G Fannon; L Tennakoon; M Santamaria; W Soni; R G Morris; T Sharma

Neuropsychological functioning in first-episode psychosis - evidence of specific deficits

E M Riley, D McGovern, D Mockler, V C K Doku, S OCeallaigh, D G Fannon, L Tennakoon, M Santamaria, W Soni, R G Morris, T Sharma

Psychology

Research output: Contribution to journal › Conference paper

181 Citations (Scopus)

Abstract

Neuropsychological impairment is ubiquitous in schizophrenia even at the first presentation of psychotic symptoms. We sought to elucidate the nature of the neuropsychological profile at the onset of the illness by examining the neuropsychological functioning of 40 patients experiencing their first episode of psychosis and 22 matched controls. All participants completed a battery of neuropsychological tasks designed to assess attention, verbal learning/memory, non-verbal memory, spatial ability, psychomotor speed, and executive function. First-episode patients showed significant impairment on tasks of executive function, including those requiring the ability to form and initiate a strategy, to inhibit prepotent responses, and to shift cognitive set, and also on tasks of verbal fluency. Memory impairments were seen on verbal learning and delayed non-verbal memory only, impairment on tasks of psychomotor speed suggests that there may be a significant amount of cognitive slowing even at the first onset of psychosis. We suggest that our patients may be experiencing difficulty in specific aspects of executive functions, including the ability to form and execute a strategy, and these difficulties may be mediating the deficits observed on tasks of verbal learning. (C) 2000 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	47 - 55
Number of pages	9
Journal	Schizophrenia Research
Volume	43
Issue number	1
Publication status	Published - 25 May 2000
Event	4th Biennial MT Sinai Conference on Cognition in Schizophrenia - SANTA FE, NEW MEXICO Duration: 1 Jan 2000 → …

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title = "Neuropsychological functioning in first-episode psychosis - evidence of specific deficits",

abstract = "Neuropsychological impairment is ubiquitous in schizophrenia even at the first presentation of psychotic symptoms. We sought to elucidate the nature of the neuropsychological profile at the onset of the illness by examining the neuropsychological functioning of 40 patients experiencing their first episode of psychosis and 22 matched controls. All participants completed a battery of neuropsychological tasks designed to assess attention, verbal learning/memory, non-verbal memory, spatial ability, psychomotor speed, and executive function. First-episode patients showed significant impairment on tasks of executive function, including those requiring the ability to form and initiate a strategy, to inhibit prepotent responses, and to shift cognitive set, and also on tasks of verbal fluency. Memory impairments were seen on verbal learning and delayed non-verbal memory only, impairment on tasks of psychomotor speed suggests that there may be a significant amount of cognitive slowing even at the first onset of psychosis. We suggest that our patients may be experiencing difficulty in specific aspects of executive functions, including the ability to form and execute a strategy, and these difficulties may be mediating the deficits observed on tasks of verbal learning. (C) 2000 Elsevier Science B.V. All rights reserved.",

author = "Riley, {E M} and D McGovern and D Mockler and Doku, {V C K} and S OCeallaigh and Fannon, {D G} and L Tennakoon and M Santamaria and W Soni and Morris, {R G} and T Sharma",

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AU - Riley, E M

AU - McGovern, D

AU - Mockler, D

AU - Doku, V C K

AU - OCeallaigh, S

AU - Fannon, D G

AU - Tennakoon, L

AU - Santamaria, M

AU - Soni, W

AU - Morris, R G

AU - Sharma, T

PY - 2000/5/25

Y1 - 2000/5/25

N2 - Neuropsychological impairment is ubiquitous in schizophrenia even at the first presentation of psychotic symptoms. We sought to elucidate the nature of the neuropsychological profile at the onset of the illness by examining the neuropsychological functioning of 40 patients experiencing their first episode of psychosis and 22 matched controls. All participants completed a battery of neuropsychological tasks designed to assess attention, verbal learning/memory, non-verbal memory, spatial ability, psychomotor speed, and executive function. First-episode patients showed significant impairment on tasks of executive function, including those requiring the ability to form and initiate a strategy, to inhibit prepotent responses, and to shift cognitive set, and also on tasks of verbal fluency. Memory impairments were seen on verbal learning and delayed non-verbal memory only, impairment on tasks of psychomotor speed suggests that there may be a significant amount of cognitive slowing even at the first onset of psychosis. We suggest that our patients may be experiencing difficulty in specific aspects of executive functions, including the ability to form and execute a strategy, and these difficulties may be mediating the deficits observed on tasks of verbal learning. (C) 2000 Elsevier Science B.V. All rights reserved.

AB - Neuropsychological impairment is ubiquitous in schizophrenia even at the first presentation of psychotic symptoms. We sought to elucidate the nature of the neuropsychological profile at the onset of the illness by examining the neuropsychological functioning of 40 patients experiencing their first episode of psychosis and 22 matched controls. All participants completed a battery of neuropsychological tasks designed to assess attention, verbal learning/memory, non-verbal memory, spatial ability, psychomotor speed, and executive function. First-episode patients showed significant impairment on tasks of executive function, including those requiring the ability to form and initiate a strategy, to inhibit prepotent responses, and to shift cognitive set, and also on tasks of verbal fluency. Memory impairments were seen on verbal learning and delayed non-verbal memory only, impairment on tasks of psychomotor speed suggests that there may be a significant amount of cognitive slowing even at the first onset of psychosis. We suggest that our patients may be experiencing difficulty in specific aspects of executive functions, including the ability to form and execute a strategy, and these difficulties may be mediating the deficits observed on tasks of verbal learning. (C) 2000 Elsevier Science B.V. All rights reserved.

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M3 - Conference paper

SN - 1573-2509

VL - 43

SP - 47

EP - 55

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

T2 - 4th Biennial MT Sinai Conference on Cognition in Schizophrenia

Y2 - 1 January 2000

ER -

Neuropsychological functioning in first-episode psychosis - evidence of specific deficits

Abstract

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