King's College London

TY - JOUR

T1 - Neuropsychological, impairments in schizophrenia: Integration of performance-based and brain imaging findings

AU - Reichenberg, A

AU - Harvey, P D

PY - 2007/9

Y1 - 2007/9

N2 - Until recently, the dominant view was that schizophrenia patients have limited, if any, neuropsychological impairments, and those that are observed are only secondary to the florid symptoms of the disorder. This view has dramatically changed. This review integrates recent evidence demonstrating the severity and profile of neuropsychological impairments in schizophrenia. We present quantitative evaluation of the literature demonstrating that the most severe impairments are apparent in episodic memory and executive control processes, evident on a background of a generalized cognitive deficit. The neuropsychological impairments potentially represent genetic liability to the disorder, as similar, yet milder, impairments are evident in schizophrenia patients even before the onset of psychotic symptoms, as well as in the notipsychotic relatives of schizophrenia patients. Corresponding cognitive neuromtaging literature on executive functions, episodic memory, and working memory in schizophrenia documenting abnormalities in frontal and medial temporal lobes is summarized, and current models integrating neuropsychological and neuromiaging data are discussed

AB - Until recently, the dominant view was that schizophrenia patients have limited, if any, neuropsychological impairments, and those that are observed are only secondary to the florid symptoms of the disorder. This view has dramatically changed. This review integrates recent evidence demonstrating the severity and profile of neuropsychological impairments in schizophrenia. We present quantitative evaluation of the literature demonstrating that the most severe impairments are apparent in episodic memory and executive control processes, evident on a background of a generalized cognitive deficit. The neuropsychological impairments potentially represent genetic liability to the disorder, as similar, yet milder, impairments are evident in schizophrenia patients even before the onset of psychotic symptoms, as well as in the notipsychotic relatives of schizophrenia patients. Corresponding cognitive neuromtaging literature on executive functions, episodic memory, and working memory in schizophrenia documenting abnormalities in frontal and medial temporal lobes is summarized, and current models integrating neuropsychological and neuromiaging data are discussed

U2 - 10.1037/0033-2909.133.5.833

DO - 10.1037/0033-2909.133.5.833

M3 - Literature review

VL - 133

SP - 833

EP - 858

JO - Psychological Bulletin

JF - Psychological Bulletin

SN - 0033-2909

IS - 5

ER -