Neurotrophic factors and their inhibitors in chronic pain treatment.

Jayne H. Kelleher; Damini Tewari; Stephen B. McMahon

doi:10.1016/j.nbd.2016.03.025

Neurotrophic factors and their inhibitors in chronic pain treatment.

Jayne H. Kelleher, Damini Tewari, Stephen B. McMahon

Wolfson SPaRC

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Abstract

Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.

Original language	English
Pages (from-to)	127-138
Journal	Neurobiology of Disease
Volume	97
Issue number	Part B
Early online date	7 Apr 2016
DOIs	https://doi.org/10.1016/j.nbd.2016.03.025
Publication status	Published - Jan 2017

Keywords

NGF
IL6
Pain
Clinical trial

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10.1016/j.nbd.2016.03.025

1-s2.0-S0969996116300717-mainAccepted author manuscript, 1.15 MBLicence: CC BY-NC-ND

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title = "Neurotrophic factors and their inhibitors in chronic pain treatment.",

abstract = "Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.",

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AB - Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.

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KW - IL6

KW - Pain

KW - Clinical trial

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JO - Neurobiology of Disease

JF - Neurobiology of Disease

IS - Part B

ER -

Neurotrophic factors and their inhibitors in chronic pain treatment.

Abstract

Keywords

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