Neurotrophic factors and their inhibitors in chronic pain treatment.

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Chronic pain affects more than 20% of the UK population. Neurotrophic factors have been identified as therapeutic targets to improve current treatments of chronic pain. This review article focuses on nerve growth factor (NGF) and interleukin-6 (IL-6) as potential therapeutic targets. In this review we highlight the mechanisms of action and the current progress of targeted therapies in clinical trials.
Original languageEnglish
Pages (from-to)127-138
JournalNeurobiology of Disease
Issue numberPart B
Early online date7 Apr 2016
Publication statusPublished - Jan 2017


  • NGF
  • IL6
  • Pain
  • Clinical trial


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