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Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy

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Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy. / Wang, Julie Tzu-Wen; Spinato, Cinzia; Klippstein, Rebecca; Costa, Pedro Miguel; Martincic, Markus; Pach, Elzbieta; Ruiz De Garibay, Aritz Perez; Ménard-moyon, Cécilia; Feldman, Robert; Michel, Yves; Šefl, Martin; Kyriakou, Ioanna; Emfietzoglou, Dimitris; Saccavini, Jean-Claude; Ballesteros, Belén; Tobias, Gerard; Bianco, Alberto; Al-Jamal, Khuloud T.

In: CARBON, Vol. 162, 06.2020, p. 410-422.

Research output: Contribution to journalArticle

Harvard

Wang, JT-W, Spinato, C, Klippstein, R, Costa, PM, Martincic, M, Pach, E, Ruiz De Garibay, AP, Ménard-moyon, C, Feldman, R, Michel, Y, Šefl, M, Kyriakou, I, Emfietzoglou, D, Saccavini, J-C, Ballesteros, B, Tobias, G, Bianco, A & Al-Jamal, KT 2020, 'Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy', CARBON, vol. 162, pp. 410-422. https://doi.org/10.1016/j.carbon.2020.02.060

APA

Wang, J. T-W., Spinato, C., Klippstein, R., Costa, P. M., Martincic, M., Pach, E., ... Al-Jamal, K. T. (2020). Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy. CARBON, 162, 410-422. https://doi.org/10.1016/j.carbon.2020.02.060

Vancouver

Wang JT-W, Spinato C, Klippstein R, Costa PM, Martincic M, Pach E et al. Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy. CARBON. 2020 Jun;162:410-422. https://doi.org/10.1016/j.carbon.2020.02.060

Author

Wang, Julie Tzu-Wen ; Spinato, Cinzia ; Klippstein, Rebecca ; Costa, Pedro Miguel ; Martincic, Markus ; Pach, Elzbieta ; Ruiz De Garibay, Aritz Perez ; Ménard-moyon, Cécilia ; Feldman, Robert ; Michel, Yves ; Šefl, Martin ; Kyriakou, Ioanna ; Emfietzoglou, Dimitris ; Saccavini, Jean-Claude ; Ballesteros, Belén ; Tobias, Gerard ; Bianco, Alberto ; Al-Jamal, Khuloud T. / Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy. In: CARBON. 2020 ; Vol. 162. pp. 410-422.

Bibtex Download

@article{05b9007873c146bea4bf3c66f52a89d0,
title = "Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy",
abstract = "Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy cancer cells. Our team has pioneered neutron activation of 152Sm, filled and sealed into single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), to create stable and high-dose radioactive carbon nanocapsules for cancer radiotherapy. In this work, MWCNTs filled with enriched 152SmCl3 (Sm@MWCNTs) were sealed and irradiated, followed by surface functionalisation with an epidermal growth factor receptor (EGFR)-targeting antibody. Characterisation of functionalised Sm@MWCNTs was carried out using thermogravimetric analysis, gel electrophoresis and transmission electron microscopy. The organ biodistribution of the radioactive functionalised 153Sm@MWCNTs and therapeutic efficacy were studied in an experimental melanoma lung metastatic tumour model in mice after intravenous injection. Quantitative biodistribution analyses showed high accumulation of 153Sm@MWCNT-Ab in lung. Significant tumour growth reduction was induced by both treatments of 153Sm@MWCNTs functionalised with or without the antibody after a single intravenous injection. Although EGFR targeting showed no improvement in therapeutic efficacy, reduced spleen toxicity and normal haematological profiles were obtained for both functionalised derivatives. The current study demonstrated the possibility of performing chemical functionalisation and antibody conjugation on radioactive nanocapsules post-irradiation for the preparation of targeted radiopharmaceuticals.",
author = "Wang, {Julie Tzu-Wen} and Cinzia Spinato and Rebecca Klippstein and Costa, {Pedro Miguel} and Markus Martincic and Elzbieta Pach and {Ruiz De Garibay}, {Aritz Perez} and C{\'e}cilia M{\'e}nard-moyon and Robert Feldman and Yves Michel and Martin Šefl and Ioanna Kyriakou and Dimitris Emfietzoglou and Jean-Claude Saccavini and Bel{\'e}n Ballesteros and Gerard Tobias and Alberto Bianco and Al-Jamal, {Khuloud T.}",
year = "2020",
month = "6",
doi = "10.1016/j.carbon.2020.02.060",
language = "English",
volume = "162",
pages = "410--422",
journal = "CARBON",
issn = "0008-6223",
publisher = "Elsevier Limited",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Neutron-irradiated antibody-functionalised carbon nanocapsules for targeted cancer radiotherapy

AU - Wang, Julie Tzu-Wen

AU - Spinato, Cinzia

AU - Klippstein, Rebecca

AU - Costa, Pedro Miguel

AU - Martincic, Markus

AU - Pach, Elzbieta

AU - Ruiz De Garibay, Aritz Perez

AU - Ménard-moyon, Cécilia

AU - Feldman, Robert

AU - Michel, Yves

AU - Šefl, Martin

AU - Kyriakou, Ioanna

AU - Emfietzoglou, Dimitris

AU - Saccavini, Jean-Claude

AU - Ballesteros, Belén

AU - Tobias, Gerard

AU - Bianco, Alberto

AU - Al-Jamal, Khuloud T.

PY - 2020/6

Y1 - 2020/6

N2 - Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy cancer cells. Our team has pioneered neutron activation of 152Sm, filled and sealed into single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), to create stable and high-dose radioactive carbon nanocapsules for cancer radiotherapy. In this work, MWCNTs filled with enriched 152SmCl3 (Sm@MWCNTs) were sealed and irradiated, followed by surface functionalisation with an epidermal growth factor receptor (EGFR)-targeting antibody. Characterisation of functionalised Sm@MWCNTs was carried out using thermogravimetric analysis, gel electrophoresis and transmission electron microscopy. The organ biodistribution of the radioactive functionalised 153Sm@MWCNTs and therapeutic efficacy were studied in an experimental melanoma lung metastatic tumour model in mice after intravenous injection. Quantitative biodistribution analyses showed high accumulation of 153Sm@MWCNT-Ab in lung. Significant tumour growth reduction was induced by both treatments of 153Sm@MWCNTs functionalised with or without the antibody after a single intravenous injection. Although EGFR targeting showed no improvement in therapeutic efficacy, reduced spleen toxicity and normal haematological profiles were obtained for both functionalised derivatives. The current study demonstrated the possibility of performing chemical functionalisation and antibody conjugation on radioactive nanocapsules post-irradiation for the preparation of targeted radiopharmaceuticals.

AB - Radiotherapy is a cancer treatment utilising high doses of ionizing radiation to destroy cancer cells. Our team has pioneered neutron activation of 152Sm, filled and sealed into single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), to create stable and high-dose radioactive carbon nanocapsules for cancer radiotherapy. In this work, MWCNTs filled with enriched 152SmCl3 (Sm@MWCNTs) were sealed and irradiated, followed by surface functionalisation with an epidermal growth factor receptor (EGFR)-targeting antibody. Characterisation of functionalised Sm@MWCNTs was carried out using thermogravimetric analysis, gel electrophoresis and transmission electron microscopy. The organ biodistribution of the radioactive functionalised 153Sm@MWCNTs and therapeutic efficacy were studied in an experimental melanoma lung metastatic tumour model in mice after intravenous injection. Quantitative biodistribution analyses showed high accumulation of 153Sm@MWCNT-Ab in lung. Significant tumour growth reduction was induced by both treatments of 153Sm@MWCNTs functionalised with or without the antibody after a single intravenous injection. Although EGFR targeting showed no improvement in therapeutic efficacy, reduced spleen toxicity and normal haematological profiles were obtained for both functionalised derivatives. The current study demonstrated the possibility of performing chemical functionalisation and antibody conjugation on radioactive nanocapsules post-irradiation for the preparation of targeted radiopharmaceuticals.

U2 - 10.1016/j.carbon.2020.02.060

DO - 10.1016/j.carbon.2020.02.060

M3 - Article

VL - 162

SP - 410

EP - 422

JO - CARBON

JF - CARBON

SN - 0008-6223

ER -

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