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New developments in imaging cell-based therapy

Research output: Contribution to journalArticlepeer-review

Olivier Martinez, Jane Sosabowski, John Maher, Sophie Papa

Original languageEnglish
Pages (from-to)730-735
Number of pages6
JournalJournal of Nuclear Medicine
Issue number6
E-pub ahead of print12 Apr 2019

King's Authors


Cancer immunotherapy is now established as a central therapeutic pillar in hematologic oncology. Cell-based therapies, with or without genetic modification ex vivo, have reached the clinic as the standard of care in limited indications and remain the subject of intense preclinical and translational development. Expanding on this, related therapeutic approaches are in development for solid-tumor and nonmalignant indications, broadening the scope of this technology. It has long been recognized that in vivo tracking of infused cellular therapies would provide unique opportunities to optimize their efficacy and aid in the assessment and management of toxicity. Recently, we have witnessed the introduction of novel tracers for passive labeling of cell products and advances in the introduction and use of reporter genes to enable longitudinal imaging. This review highlights the key developments over the last 5 y.

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