New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families

G Kalsi; B Mankoo; D Curtis; R Sherrington; G Melmer; J Brynjolfsson; T Sigmundsson; T Read; P Murphy; H Petersson; H Gurling

New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families

G Kalsi^*, B Mankoo, D Curtis, R Sherrington, G Melmer, J Brynjolfsson, T Sigmundsson, T Read, P Murphy, H Petersson, H Gurling

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Genetic linkage of schizophrenia to markers at 5q11.2-13.3 had been reported previously in five Icelandic and two British families, but attempts at replication in independent samples have been unsuccessful. We report here an update on the diagnoses and results of linkage analyses using newer highly polymorphic microsatellite markers at or near the loci D5S76 and D5S39 in the original sample of pedigrees and in two new family samples from Iceland and from Britain. The new results show a reduction in evidence for linkage in the original sample and evidence against linkage in the two new family samples. Although it is possible that a rare locus is present, perhaps in the region 5p14.1-13.1 rather than 5q11.2-13.3, it appears most likely that the original positive lod scores represent an exaggeration of the 'true' lod scores due to random effects and that the small lod scores we now obtain could have arisen by chance.

Original language	English
Pages (from-to)	235-247
Number of pages	13
Journal	Annals of Human Genetics
Volume	63
Publication status	Published - May 1999

Keywords

SHORT ARM
TIGHT LINKAGE
GENETIC-LINKAGE
GENOME SCAN
RFLP
REGION
RECEPTOR GENE
MAP
MENTAL-ILLNESS
PARTIAL TRISOMY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Kalsi, G., Mankoo, B., Curtis, D., Sherrington, R., Melmer, G., Brynjolfsson, J., Sigmundsson, T., Read, T., Murphy, P., Petersson, H., & Gurling, H. (1999). New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families. Annals of Human Genetics, 63, 235-247.

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title = "New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families",

abstract = "Genetic linkage of schizophrenia to markers at 5q11.2-13.3 had been reported previously in five Icelandic and two British families, but attempts at replication in independent samples have been unsuccessful. We report here an update on the diagnoses and results of linkage analyses using newer highly polymorphic microsatellite markers at or near the loci D5S76 and D5S39 in the original sample of pedigrees and in two new family samples from Iceland and from Britain. The new results show a reduction in evidence for linkage in the original sample and evidence against linkage in the two new family samples. Although it is possible that a rare locus is present, perhaps in the region 5p14.1-13.1 rather than 5q11.2-13.3, it appears most likely that the original positive lod scores represent an exaggeration of the 'true' lod scores due to random effects and that the small lod scores we now obtain could have arisen by chance.",

keywords = "SHORT ARM, TIGHT LINKAGE, GENETIC-LINKAGE, GENOME SCAN, RFLP, REGION, RECEPTOR GENE, MAP, MENTAL-ILLNESS, PARTIAL TRISOMY",

author = "G Kalsi and B Mankoo and D Curtis and R Sherrington and G Melmer and J Brynjolfsson and T Sigmundsson and T Read and P Murphy and H Petersson and H Gurling",

year = "1999",

month = may,

language = "English",

volume = "63",

pages = "235--247",

journal = "Annals of Human Genetics",

issn = "0003-4800",

publisher = "Wiley-Blackwell",

}

Kalsi, G , Mankoo, B, Curtis, D, Sherrington, R, Melmer, G, Brynjolfsson, J, Sigmundsson, T, Read, T, Murphy, P, Petersson, H & Gurling, H 1999, 'New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families', Annals of Human Genetics, vol. 63, pp. 235-247.

New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families. / Kalsi, G ; Mankoo, B; Curtis, D et al.
In: Annals of Human Genetics, Vol. 63, 05.1999, p. 235-247.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families

AU - Kalsi, G

AU - Mankoo, B

AU - Curtis, D

AU - Sherrington, R

AU - Melmer, G

AU - Brynjolfsson, J

AU - Sigmundsson, T

AU - Read, T

AU - Murphy, P

AU - Petersson, H

AU - Gurling, H

PY - 1999/5

Y1 - 1999/5

N2 - Genetic linkage of schizophrenia to markers at 5q11.2-13.3 had been reported previously in five Icelandic and two British families, but attempts at replication in independent samples have been unsuccessful. We report here an update on the diagnoses and results of linkage analyses using newer highly polymorphic microsatellite markers at or near the loci D5S76 and D5S39 in the original sample of pedigrees and in two new family samples from Iceland and from Britain. The new results show a reduction in evidence for linkage in the original sample and evidence against linkage in the two new family samples. Although it is possible that a rare locus is present, perhaps in the region 5p14.1-13.1 rather than 5q11.2-13.3, it appears most likely that the original positive lod scores represent an exaggeration of the 'true' lod scores due to random effects and that the small lod scores we now obtain could have arisen by chance.

AB - Genetic linkage of schizophrenia to markers at 5q11.2-13.3 had been reported previously in five Icelandic and two British families, but attempts at replication in independent samples have been unsuccessful. We report here an update on the diagnoses and results of linkage analyses using newer highly polymorphic microsatellite markers at or near the loci D5S76 and D5S39 in the original sample of pedigrees and in two new family samples from Iceland and from Britain. The new results show a reduction in evidence for linkage in the original sample and evidence against linkage in the two new family samples. Although it is possible that a rare locus is present, perhaps in the region 5p14.1-13.1 rather than 5q11.2-13.3, it appears most likely that the original positive lod scores represent an exaggeration of the 'true' lod scores due to random effects and that the small lod scores we now obtain could have arisen by chance.

KW - SHORT ARM

KW - TIGHT LINKAGE

KW - GENETIC-LINKAGE

KW - GENOME SCAN

KW - RFLP

KW - REGION

KW - RECEPTOR GENE

KW - MAP

KW - MENTAL-ILLNESS

KW - PARTIAL TRISOMY

M3 - Article

SN - 0003-4800

VL - 63

SP - 235

EP - 247

JO - Annals of Human Genetics

JF - Annals of Human Genetics

ER -

New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families

Abstract

Keywords

UN SDGs

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