New frontiers in suicide vulnerability: immune system and sex hormones

Giulia Lombardo

doi:doi: 10.1016/j.bbih.2021.100384

New frontiers in suicide vulnerability: immune system and sex hormones

Giulia Lombardo

Psychological Medicine

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Suicide is one of the leading causes of death worldwide and men have a higher risk of attempting and completing suicide than women. Accumulating evidence leads to a possible key role of the immune system and sex hormones in psychiatric conditions associated with suicide vulnerability (e.g., major depressive disorder). Moreover, the literature highlights a dysregulation of the immune system and altered sex hormone levels in suicidal patients. Sex hormones and the immune system may have a role in suicide risk and sex differences in suicide vulnerability. This brief review emphasises a research area focused on a possible interplay between the immune system and sex hormones that may help develop a better understanding of suicide vulnerability in the perspective of sex-specific therapeutic approaches.

Original language	English
Journal	Brain, Behavior, & Immunity - Health
Volume	18
DOIs	https://doi.org/doi: 10.1016/j.bbih.2021.100384
Publication status	Published - Nov 2021

Keywords

suicide
sex hormones
Immune system
Sex differences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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doi: 10.1016/j.bbih.2021.100384

Cite this

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title = "New frontiers in suicide vulnerability: immune system and sex hormones",

abstract = "Suicide is one of the leading causes of death worldwide and men have a higher risk of attempting and completing suicide than women. Accumulating evidence leads to a possible key role of the immune system and sex hormones in psychiatric conditions associated with suicide vulnerability (e.g., major depressive disorder). Moreover, the literature highlights a dysregulation of the immune system and altered sex hormone levels in suicidal patients. Sex hormones and the immune system may have a role in suicide risk and sex differences in suicide vulnerability. This brief review emphasises a research area focused on a possible interplay between the immune system and sex hormones that may help develop a better understanding of suicide vulnerability in the perspective of sex-specific therapeutic approaches.",

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AU - Lombardo, Giulia

PY - 2021/11

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N2 - Suicide is one of the leading causes of death worldwide and men have a higher risk of attempting and completing suicide than women. Accumulating evidence leads to a possible key role of the immune system and sex hormones in psychiatric conditions associated with suicide vulnerability (e.g., major depressive disorder). Moreover, the literature highlights a dysregulation of the immune system and altered sex hormone levels in suicidal patients. Sex hormones and the immune system may have a role in suicide risk and sex differences in suicide vulnerability. This brief review emphasises a research area focused on a possible interplay between the immune system and sex hormones that may help develop a better understanding of suicide vulnerability in the perspective of sex-specific therapeutic approaches.

AB - Suicide is one of the leading causes of death worldwide and men have a higher risk of attempting and completing suicide than women. Accumulating evidence leads to a possible key role of the immune system and sex hormones in psychiatric conditions associated with suicide vulnerability (e.g., major depressive disorder). Moreover, the literature highlights a dysregulation of the immune system and altered sex hormone levels in suicidal patients. Sex hormones and the immune system may have a role in suicide risk and sex differences in suicide vulnerability. This brief review emphasises a research area focused on a possible interplay between the immune system and sex hormones that may help develop a better understanding of suicide vulnerability in the perspective of sex-specific therapeutic approaches.

KW - suicide

KW - sex hormones

KW - Immune system

KW - Sex differences

U2 - doi: 10.1016/j.bbih.2021.100384

DO - doi: 10.1016/j.bbih.2021.100384

M3 - Review article

SN - 2666-3546

VL - 18

JO - Brain, Behavior, & Immunity - Health

JF - Brain, Behavior, & Immunity - Health

ER -

New frontiers in suicide vulnerability: immune system and sex hormones

Abstract

Keywords

UN SDGs

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