New insights into an X-traordinary viral protein

Torsten Schaller; Helene Bauby; Stephane Hue; Michael H. Malim; Caroline Goujon

doi:10.3389/fmicb.2014.00126

New insights into an X-traordinary viral protein

Torsten Schaller, Helene Bauby, Stephane Hue, Michael H. Malim, Caroline Goujon^*

^*Corresponding author for this work

Infectious Diseases

UCL University College London

Research output: Contribution to journal › Literature review › peer-review

20 Citations (Scopus)

Abstract

Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.

Original language	English
Article number	126
Pages (from-to)	N/A
Number of pages	14
Journal	Frontiers in microbiology
Volume	5
Issue number	N/A
DOIs	https://doi.org/10.3389/fmicb.2014.00126
Publication status	Published - 8 Apr 2014

Keywords

vpx
HIV-2
SIVsmm
SAMHD1
myeloid cells
HIV-1
restriction factor
interferon type 1
HUMAN-IMMUNODEFICIENCY-VIRUS
AICARDI-GOUTIERES-SYNDROME
RESTRICTION FACTOR SAMHD1
NUCLEAR-LOCALIZATION SIGNAL
BLOOD MONONUCLEAR-CELLS
GAMMA-INDUCED PROTEIN
HUMAN DENDRITIC CELLS
CD4(+) T-LYMPHOCYTES
VPX PROTEIN
TYPE-2 VPX

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fmicb.2014.00126

Cite this

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title = "New insights into an X-traordinary viral protein",

abstract = "Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.",

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author = "Torsten Schaller and Helene Bauby and Stephane Hue and Malim, {Michael H.} and Caroline Goujon",

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doi = "10.3389/fmicb.2014.00126",

language = "English",

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journal = "Frontiers in microbiology",

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T1 - New insights into an X-traordinary viral protein

AU - Schaller, Torsten

AU - Bauby, Helene

AU - Hue, Stephane

AU - Malim, Michael H.

AU - Goujon, Caroline

PY - 2014/4/8

Y1 - 2014/4/8

N2 - Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.

AB - Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.

KW - vpx

KW - HIV-2

KW - SIVsmm

KW - SAMHD1

KW - myeloid cells

KW - HIV-1

KW - restriction factor

KW - interferon type 1

KW - HUMAN-IMMUNODEFICIENCY-VIRUS

KW - AICARDI-GOUTIERES-SYNDROME

KW - RESTRICTION FACTOR SAMHD1

KW - NUCLEAR-LOCALIZATION SIGNAL

KW - BLOOD MONONUCLEAR-CELLS

KW - GAMMA-INDUCED PROTEIN

KW - HUMAN DENDRITIC CELLS

KW - CD4(+) T-LYMPHOCYTES

KW - VPX PROTEIN

KW - TYPE-2 VPX

U2 - 10.3389/fmicb.2014.00126

DO - 10.3389/fmicb.2014.00126

M3 - Literature review

SN - 1664-302X

VL - 5

SP - N/A

JO - Frontiers in microbiology

JF - Frontiers in microbiology

IS - N/A

M1 - 126

ER -

New insights into an X-traordinary viral protein

Abstract

Keywords

UN SDGs

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