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New insights into an X-traordinary viral protein

Research output: Contribution to journalLiterature review

Original languageEnglish
Article number126
Pages (from-to)N/A
Number of pages14
JournalFrontiers in microbiology
Issue numberN/A
Published8 Apr 2014

King's Authors


Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.

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