New insights into the functional impact of G protein–coupled receptor oligomerization

Gillian P. Johnson; Uche Agwuegbo; Kim C. Jonas

doi:10.1016/j.coemr.2020.08.005

New insights into the functional impact of G protein–coupled receptor oligomerization

Gillian P. Johnson, Uche Agwuegbo, Kim C. Jonas^*

^*Corresponding author for this work

Women & Children's Health

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

The classical idea of a G protein–coupled receptor (GPCR) activating a single signal pathway has been superseded by the concept of functional pleiotropy for this receptor superfamily. One mechanism that has been shown to facilitate such multifaceted roles of GPCRs is the association of GPCRs to form dimers and oligomers, either with self (homomerization) or distinct GPCRs (heteromerization). This review explores the recent advances in our understanding of the structural and functional complexities of GPCR di/oligomerization, describing how our evolving models of these receptor complexes may provide novel and more selective modes of pharmacological tuning.

Original language	English
Pages (from-to)	43-50
Number of pages	8
Journal	Current Opinion in Endocrine and Metabolic Research
Volume	16
DOIs	https://doi.org/10.1016/j.coemr.2020.08.005
Publication status	Published - Feb 2021

Keywords

Dimerization
GPCR
Heteromer
Homomer
Oligomerization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coemr.2020.08.005

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title = "New insights into the functional impact of G protein–coupled receptor oligomerization",

abstract = "The classical idea of a G protein–coupled receptor (GPCR) activating a single signal pathway has been superseded by the concept of functional pleiotropy for this receptor superfamily. One mechanism that has been shown to facilitate such multifaceted roles of GPCRs is the association of GPCRs to form dimers and oligomers, either with self (homomerization) or distinct GPCRs (heteromerization). This review explores the recent advances in our understanding of the structural and functional complexities of GPCR di/oligomerization, describing how our evolving models of these receptor complexes may provide novel and more selective modes of pharmacological tuning.",

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T1 - New insights into the functional impact of G protein–coupled receptor oligomerization

AU - Johnson, Gillian P.

AU - Agwuegbo, Uche

AU - Jonas, Kim C.

PY - 2021/2

Y1 - 2021/2

N2 - The classical idea of a G protein–coupled receptor (GPCR) activating a single signal pathway has been superseded by the concept of functional pleiotropy for this receptor superfamily. One mechanism that has been shown to facilitate such multifaceted roles of GPCRs is the association of GPCRs to form dimers and oligomers, either with self (homomerization) or distinct GPCRs (heteromerization). This review explores the recent advances in our understanding of the structural and functional complexities of GPCR di/oligomerization, describing how our evolving models of these receptor complexes may provide novel and more selective modes of pharmacological tuning.

AB - The classical idea of a G protein–coupled receptor (GPCR) activating a single signal pathway has been superseded by the concept of functional pleiotropy for this receptor superfamily. One mechanism that has been shown to facilitate such multifaceted roles of GPCRs is the association of GPCRs to form dimers and oligomers, either with self (homomerization) or distinct GPCRs (heteromerization). This review explores the recent advances in our understanding of the structural and functional complexities of GPCR di/oligomerization, describing how our evolving models of these receptor complexes may provide novel and more selective modes of pharmacological tuning.

KW - Dimerization

KW - GPCR

KW - Heteromer

KW - Homomer

KW - Oligomerization

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U2 - 10.1016/j.coemr.2020.08.005

DO - 10.1016/j.coemr.2020.08.005

M3 - Review article

AN - SCOPUS:85091535940

SN - 2451-9650

VL - 16

SP - 43

EP - 50

JO - Current Opinion in Endocrine and Metabolic Research

JF - Current Opinion in Endocrine and Metabolic Research

ER -

New insights into the functional impact of G protein–coupled receptor oligomerization

Abstract

Keywords

UN SDGs

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