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New perspectives on integrin-dependent adhesions

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume63
Early online date13 Jan 2020
DOIs
Publication statusE-pub ahead of print - 13 Jan 2020

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Abstract

Integrins are heterodimeric transmembrane receptors that connect the extracellular matrix environment to the actin cytoskeleton via adaptor molecules through assembly of a range of adhesion structures. Recent advances in biochemical, imaging and biophysical methods have enabled a deeper understanding of integrin signalling and their associated regulatory processes. The identification of the consensus integrin-based ‘adhesomes’ within the last 5 years has defined common core components of adhesion complexes and associated partners. These approaches have also uncovered unexpected adhesion protein behaviour and molecules recruited to adhesion sites that have expanded our understanding of the molecular and physical control of integrin signalling.

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