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Nitrous oxide inhalation sedation in dentistry: An overview of its applications and safety profile

Research output: Contribution to journalArticle

Ruixiang Yee, Danny Wong, Pui Ling Chay, Vivian Yung Yee Wong, Chai Kiat Chng, Marie-Therese Hosey

Original languageEnglish
Pages (from-to)1-9
Number of pages10
Publication statusPublished - 31 May 2019

King's Authors


Nitrous oxide in oxygen (N2O/O2) inhalation sedation is used less commonly by Singapore dentists than their counterparts in the United Kingdom and the United States. Using this technique, trained dentists often perform the dual roles of a sedationist and an operating dentist. This paper describes the mechanism of action of N2O and highlights the modern gas delivery system commonly used in dentistry. The built-in safety features of this unique system helps to ensure that patient-specific therapeutic dosages are effectively and safely administered by dentists. Existing evidence for adverse events and the safety profile of the N2O/O2 inhalation sedation is discussed. Finally, recommendations of equipment, training and techniques for safe N2O/O2 inhalation sedation are provided.

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