No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

Penelope A. Lind; Michelle Luciano; Michael A. Horan; Riccardo E. Marioni; Margaret J. Wright; Timothy C. Bates; Patrick Rabbitt; Sarah E. Harris; Yvonne Davidson; Ian J. Deary; Linda Gibbons; Andrew Pickles; William Ollier; Neil Pendleton; Jackie F. Price; Antony Payton; Nicholas G. Martin

doi:10.1007/s10519-009-9274-z

No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

Penelope A. Lind, Michelle Luciano, Michael A. Horan, Riccardo E. Marioni, Margaret J. Wright, Timothy C. Bates, Patrick Rabbitt, Sarah E. Harris, Yvonne Davidson, Ian J. Deary, Linda Gibbons, Andrew Pickles, William Ollier, Neil Pendleton, Jackie F. Price, Antony Payton, Nicholas G. Martin

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Abstract

Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.

Original language	English
Pages (from-to)	513-523
Number of pages	11
Journal	Behavior Genetics
Volume	39
Issue number	5
DOIs	https://doi.org/10.1007/s10519-009-9274-z
Publication status	Published - Sept 2009

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Lind, P. A., Luciano, M., Horan, M. A., Marioni, R. E., Wright, M. J., Bates, T. C., Rabbitt, P., Harris, S. E., Davidson, Y., Deary, I. J., Gibbons, L., Pickles, A., Ollier, W., Pendleton, N., Price, J. F., Payton, A., & Martin, N. G. (2009). No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples. Behavior Genetics, 39(5), 513-523. https://doi.org/10.1007/s10519-009-9274-z

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title = "No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples",

abstract = "Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.",

author = "Lind, {Penelope A.} and Michelle Luciano and Horan, {Michael A.} and Marioni, {Riccardo E.} and Wright, {Margaret J.} and Bates, {Timothy C.} and Patrick Rabbitt and Harris, {Sarah E.} and Yvonne Davidson and Deary, {Ian J.} and Linda Gibbons and Andrew Pickles and William Ollier and Neil Pendleton and Price, {Jackie F.} and Antony Payton and Martin, {Nicholas G.}",

year = "2009",

month = sep,

doi = "10.1007/s10519-009-9274-z",

language = "English",

volume = "39",

pages = "513--523",

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Lind, PA, Luciano, M, Horan, MA, Marioni, RE, Wright, MJ, Bates, TC, Rabbitt, P, Harris, SE, Davidson, Y, Deary, IJ, Gibbons, L, Pickles, A, Ollier, W, Pendleton, N, Price, JF, Payton, A & Martin, NG 2009, 'No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples', Behavior Genetics, vol. 39, no. 5, pp. 513-523. https://doi.org/10.1007/s10519-009-9274-z

TY - JOUR

T1 - No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

AU - Lind, Penelope A.

AU - Luciano, Michelle

AU - Horan, Michael A.

AU - Marioni, Riccardo E.

AU - Wright, Margaret J.

AU - Bates, Timothy C.

AU - Rabbitt, Patrick

AU - Harris, Sarah E.

AU - Davidson, Yvonne

AU - Deary, Ian J.

AU - Gibbons, Linda

AU - Pickles, Andrew

AU - Ollier, William

AU - Pendleton, Neil

AU - Price, Jackie F.

AU - Payton, Antony

AU - Martin, Nicholas G.

PY - 2009/9

Y1 - 2009/9

N2 - Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.

AB - Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.

U2 - 10.1007/s10519-009-9274-z

DO - 10.1007/s10519-009-9274-z

M3 - Article

SN - 0001-8244

VL - 39

SP - 513

EP - 523

JO - Behavior Genetics

JF - Behavior Genetics

IS - 5

ER -

No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

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