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No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

Research output: Contribution to journalArticle

Penelope A. Lind, Michelle Luciano, Michael A. Horan, Riccardo E. Marioni, Margaret J. Wright, Timothy C. Bates, Patrick Rabbitt, Sarah E. Harris, Yvonne Davidson, Ian J. Deary, Linda Gibbons, Andrew Pickles, William Ollier, Neil Pendleton, Jackie F. Price, Antony Payton, Nicholas G. Martin

Original languageEnglish
Pages (from-to)513-523
Number of pages11
JournalBehavior Genetics
Issue number5
Publication statusPublished - Sep 2009

King's Authors


Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.

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