No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

S A Petrill; R Plomin; G E McClearn; D L Smith; S Vignetti; M J Chorney; K Chorney; L A Thompson; D K Detterman; C Benbow; D Lubinski; J Daniels; M Owen; P McGuffin

doi:10.1023/A:1025659124405

No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

S A Petrill, R Plomin, G E McClearn, D L Smith, S Vignetti, M J Chorney, K Chorney, L A Thompson, D K Detterman, C Benbow, D Lubinski, J Daniels, M Owen, P McGuffin

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

Original language	English
Pages (from-to)	29-31
Number of pages	3
Journal	Behavior Genetics
Volume	27
Issue number	1
DOIs	https://doi.org/10.1023/A:1025659124405
Publication status	Published - 1997

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Petrill, S. A., Plomin, R., McClearn, G. E., Smith, D. L., Vignetti, S., Chorney, M. J., Chorney, K., Thompson, L. A., Detterman, D. K., Benbow, C., Lubinski, D., Daniels, J., Owen, M., & McGuffin, P. (1997). No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene. Behavior Genetics, 27(1), 29-31. https://doi.org/10.1023/A:1025659124405

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abstract = "Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.",

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AU - Petrill, S A

AU - Plomin, R

AU - McClearn, G E

AU - Smith, D L

AU - Vignetti, S

AU - Chorney, M J

AU - Chorney, K

AU - Thompson, L A

AU - Detterman, D K

AU - Benbow, C

AU - Lubinski, D

AU - Daniels, J

AU - Owen, M

AU - McGuffin, P

PY - 1997

Y1 - 1997

N2 - Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

AB - Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

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DO - 10.1023/A:1025659124405

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VL - 27

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EP - 31

JO - Behavior Genetics

JF - Behavior Genetics

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ER -

No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

Abstract

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