TY - JOUR
T1 - No association between genetic markers in BDNF gene and lithium prophylaxis in a Greek sample
AU - Drago, Antonio
AU - Serretti, Alessandro
AU - Smith, Rebecca
AU - Huezo-Diaz, Patricia
AU - Malitas, Petros
AU - Albani, Diego
AU - De Ronchi, Diana
AU - Pae, Chi-Un
AU - Aitchison, Katherine J.
PY - 2010
Y1 - 2010
N2 - Lithium efficacy is, at least partially, under genetic control. We investigated the association between markers in BDNF and lithium prophylactic efficacy. A set of 10 SNPs within BDNF were genotyped in a sample of 83 bipolar patients. Response to lithium was assessed by presence or absence of any illness phases during a period of 3 years of longitudinal observation. No significant association was detected between the genetic variants tested in BDNF and lithium prophylaxis. Despite the negative association, limitations including small sample size suggest that larger scale genetic associations studies of these genes and lithium prophylaxis are nonetheless indicated.
AB - Lithium efficacy is, at least partially, under genetic control. We investigated the association between markers in BDNF and lithium prophylactic efficacy. A set of 10 SNPs within BDNF were genotyped in a sample of 83 bipolar patients. Response to lithium was assessed by presence or absence of any illness phases during a period of 3 years of longitudinal observation. No significant association was detected between the genetic variants tested in BDNF and lithium prophylaxis. Despite the negative association, limitations including small sample size suggest that larger scale genetic associations studies of these genes and lithium prophylaxis are nonetheless indicated.
U2 - 10.3109/13651501003706717
DO - 10.3109/13651501003706717
M3 - Article
VL - 14
SP - 154
EP - 157
JO - International Journal of Psychiatry in Clinical Practice
JF - International Journal of Psychiatry in Clinical Practice
IS - 2
ER -
