No association of salivary total tau concentration with Alzheimer's disease

Nicholas J. Ashton; Mark Ide; Michael Schöll; Kaj Blennow; Simon Lovestone; Abdul Hye; Henrik Zetterberg

doi:10.1016/j.neurobiolaging.2018.06.014

No association of salivary total tau concentration with Alzheimer's disease

Nicholas J. Ashton, Mark Ide, Michael Schöll, Kaj Blennow, Simon Lovestone, Abdul Hye, Henrik Zetterberg

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Abstract

There is a need for an accessible biomarker that can complement
current cerebrospinal fluid (CSF) and imaging biomarkers in an accurate
and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of
potential biomarkers and proteins related to neurodegenerative disorders
have been shown to be present in this matrix, including tau. In this
study, we quantified salivary total tau (t-tau) concentration in 160
healthy elderly control (HEC), 60 mild cognitive impairment (MCI) and 54
Alzheimer's disease (AD) participants using ultra-sensitive Single
molecule array (Simoa) technology. No median difference in salivary t-tau
concentration was found between AD and MCI or HEC (12.3 ng/L, 9.8 ng/L
and 9.6 ng/L, respectively, P = 0.219). In addition, there was no
association of salivary t-tau concentration with neurophysiological
assessment or structural MRI. Despite a nominal increase in AD, due to
the large overlaps in concentrations between clinical groups, we conclude
that salivary t-tau is neither a suitable biomarker for AD nor for
cognitive impairment.

Original language	English
Pages (from-to)	125-127
Number of pages	3
Journal	Neurobiology of Aging
Volume	70
Early online date	20 Jun 2018
DOIs	https://doi.org/10.1016/j.neurobiolaging.2018.06.014
Publication status	Published - Oct 2018

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10.1016/j.neurobiolaging.2018.06.014

No association of salivary total_ASHTON_Accepted11June2018_GREEN AAM
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Cite this

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title = "No association of salivary total tau concentration with Alzheimer's disease",

abstract = "There is a need for an accessible biomarker that can complementcurrent cerebrospinal fluid (CSF) and imaging biomarkers in an accurateand early diagnosis of Alzheimer disease (AD). Saliva is a rich source ofpotential biomarkers and proteins related to neurodegenerative disordershave been shown to be present in this matrix, including tau. In thisstudy, we quantified salivary total tau (t-tau) concentration in 160healthy elderly control (HEC), 60 mild cognitive impairment (MCI) and 54Alzheimer's disease (AD) participants using ultra-sensitive Singlemolecule array (Simoa) technology. No median difference in salivary t-tauconcentration was found between AD and MCI or HEC (12.3 ng/L, 9.8 ng/Land 9.6 ng/L, respectively, P = 0.219). In addition, there was noassociation of salivary t-tau concentration with neurophysiologicalassessment or structural MRI. Despite a nominal increase in AD, due tothe large overlaps in concentrations between clinical groups, we concludethat salivary t-tau is neither a suitable biomarker for AD nor forcognitive impairment.",

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T1 - No association of salivary total tau concentration with Alzheimer's disease

AU - Ashton, Nicholas J.

AU - Ide, Mark

AU - Schöll, Michael

AU - Blennow, Kaj

AU - Lovestone, Simon

AU - Hye, Abdul

AU - Zetterberg, Henrik

PY - 2018/10

Y1 - 2018/10

N2 - There is a need for an accessible biomarker that can complementcurrent cerebrospinal fluid (CSF) and imaging biomarkers in an accurateand early diagnosis of Alzheimer disease (AD). Saliva is a rich source ofpotential biomarkers and proteins related to neurodegenerative disordershave been shown to be present in this matrix, including tau. In thisstudy, we quantified salivary total tau (t-tau) concentration in 160healthy elderly control (HEC), 60 mild cognitive impairment (MCI) and 54Alzheimer's disease (AD) participants using ultra-sensitive Singlemolecule array (Simoa) technology. No median difference in salivary t-tauconcentration was found between AD and MCI or HEC (12.3 ng/L, 9.8 ng/Land 9.6 ng/L, respectively, P = 0.219). In addition, there was noassociation of salivary t-tau concentration with neurophysiologicalassessment or structural MRI. Despite a nominal increase in AD, due tothe large overlaps in concentrations between clinical groups, we concludethat salivary t-tau is neither a suitable biomarker for AD nor forcognitive impairment.

AB - There is a need for an accessible biomarker that can complementcurrent cerebrospinal fluid (CSF) and imaging biomarkers in an accurateand early diagnosis of Alzheimer disease (AD). Saliva is a rich source ofpotential biomarkers and proteins related to neurodegenerative disordershave been shown to be present in this matrix, including tau. In thisstudy, we quantified salivary total tau (t-tau) concentration in 160healthy elderly control (HEC), 60 mild cognitive impairment (MCI) and 54Alzheimer's disease (AD) participants using ultra-sensitive Singlemolecule array (Simoa) technology. No median difference in salivary t-tauconcentration was found between AD and MCI or HEC (12.3 ng/L, 9.8 ng/Land 9.6 ng/L, respectively, P = 0.219). In addition, there was noassociation of salivary t-tau concentration with neurophysiologicalassessment or structural MRI. Despite a nominal increase in AD, due tothe large overlaps in concentrations between clinical groups, we concludethat salivary t-tau is neither a suitable biomarker for AD nor forcognitive impairment.

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DO - 10.1016/j.neurobiolaging.2018.06.014

M3 - Article

SN - 0197-4580

VL - 70

SP - 125

EP - 127

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

No association of salivary total tau concentration with Alzheimer's disease

Abstract

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