No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents

Wasim Khan; Vincent Giampietro; Cedric Ginestet; Flavio Dell' Acqua; David Bouls; Steven Newhouse; Richard Dobson; Tobias Banaschewski; Gareth J Barker; Arun L W Bokde; Christian Büchel; Patricia Conrod; Herta Flor; Vincent Frouin; Hugh Garavan; Penny Gowland; Anreas Heinz; Bernd Ittermann; Hervé Lemaître; Frauke Nees; Tomas Paus; Zdenka Pausova; Marcella Rietschel; Michael N Smolka; Andreas Ströhle; Jean Gallinat; Eric Westman; Gunter Schumann; Simon Lovestone; Andrew Simmons

doi:10.3233/JAD-131841

No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents

Wasim Khan, Vincent Giampietro, Cedric Ginestet, Flavio Dell' Acqua, David Bouls, Steven Newhouse, Richard Dobson, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Christian Büchel, Patricia Conrod, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Anreas Heinz, Bernd Ittermann, Hervé Lemaître, Frauke NeesTomas Paus, Zdenka Pausova, Marcella Rietschel, Michael N Smolka, Andreas Ströhle, Jean Gallinat, Eric Westman, Gunter Schumann, Simon Lovestone, Andrew Simmons

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Abstract

Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these alleles may only become apparent in later life.

Original language	English
Pages (from-to)	37-43
Number of pages	7
Journal	Journal of Alzheimer's disease : JAD
Volume	40
Issue number	1
Early online date	10 Dec 2013
DOIs	https://doi.org/10.3233/JAD-131841
Publication status	Published - 1 Mar 2014

Keywords

Acknowledged-BRU-13/14
Acknowledged-BRU
Acknowledged-BRC
Acknowledged-BRC-13/14

Access to Document

10.3233/JAD-131841Licence: CC BY

No Differences in Hippocampal_KHAN_Acc28Oct2013_GOLD VoR(CC BY)Final published version, 73.7 KBLicence: CC BY

http://iospress.metapress.com/content/hu1g83m47w420670/?genre=article&id=doi%3a10.3233%2fJAD-131841

Cite this

Khan, W., Giampietro, V., Ginestet, C., Dell' Acqua, F., Bouls, D., Newhouse, S., Dobson, R., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Conrod, P., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaître, H., ... Simmons, A. (2014). No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents. Journal of Alzheimer's disease : JAD, 40(1), 37-43. https://doi.org/10.3233/JAD-131841

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title = "No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents",

abstract = "Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these alleles may only become apparent in later life.",

keywords = "Acknowledged-BRU-13/14, Acknowledged-BRU, Acknowledged-BRC, Acknowledged-BRC-13/14",

author = "Wasim Khan and Vincent Giampietro and Cedric Ginestet and {Dell' Acqua}, Flavio and David Bouls and Steven Newhouse and Richard Dobson and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Christian B{\"u}chel and Patricia Conrod and Herta Flor and Vincent Frouin and Hugh Garavan and Penny Gowland and Anreas Heinz and Bernd Ittermann and Herv{\'e} Lema{\^i}tre and Frauke Nees and Tomas Paus and Zdenka Pausova and Marcella Rietschel and Smolka, {Michael N} and Andreas Str{\"o}hle and Jean Gallinat and Eric Westman and Gunter Schumann and Simon Lovestone and Andrew Simmons",

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Khan, W , Giampietro, V , Ginestet, C , Dell' Acqua, F, Bouls, D, Newhouse, S , Dobson, R, Banaschewski, T, Barker, GJ, Bokde, ALW, Büchel, C, Conrod, P, Flor, H, Frouin, V, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lemaître, H, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Smolka, MN, Ströhle, A, Gallinat, J, Westman, E, Schumann, G , Lovestone, S & Simmons, A 2014, 'No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents', Journal of Alzheimer's disease : JAD, vol. 40, no. 1, pp. 37-43. https://doi.org/10.3233/JAD-131841

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T1 - No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents

AU - Khan, Wasim

AU - Giampietro, Vincent

AU - Ginestet, Cedric

AU - Dell' Acqua, Flavio

AU - Bouls, David

AU - Newhouse, Steven

AU - Dobson, Richard

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Anreas

AU - Ittermann, Bernd

AU - Lemaître, Hervé

AU - Nees, Frauke

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Rietschel, Marcella

AU - Smolka, Michael N

AU - Ströhle, Andreas

AU - Gallinat, Jean

AU - Westman, Eric

AU - Schumann, Gunter

AU - Lovestone, Simon

AU - Simmons, Andrew

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these alleles may only become apparent in later life.

AB - Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these alleles may only become apparent in later life.

KW - Acknowledged-BRU-13/14

KW - Acknowledged-BRU

KW - Acknowledged-BRC

KW - Acknowledged-BRC-13/14

U2 - 10.3233/JAD-131841

DO - 10.3233/JAD-131841

M3 - Article

C2 - 24326516

SN - 1875-8908

VL - 40

SP - 37

EP - 43

JO - Journal of Alzheimer's disease : JAD

JF - Journal of Alzheimer's disease : JAD

IS - 1

ER -