No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London

Ricardo Rojas-Garcia; Kirsten M. Scott; Jose Carlos Roche; William Scotton; Naomi Martin; Anna Janssen; Laura H. Goldstein; P. Nigel Leigh; Cathy M. Ellis; Christopher E. Shaw; Ammar Al-Chalabi

doi:10.3109/17482968.2011.636049

No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London

Ricardo Rojas-Garcia, Kirsten M. Scott, Jose Carlos Roche, William Scotton, Naomi Martin, Anna Janssen, Laura H. Goldstein, P. Nigel Leigh, Cathy M. Ellis, Christopher E. Shaw, Ammar Al-Chalabi

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Abstract

Previous studies have suggested a lower incidence of ALS in people of African origin. We used a population based register in an urban setting from inner city London postcodes where there is a large population of people of African ancestry to compare the frequency of ALS in people of European and African origin. Population statistics stratified by age, gender and ethnicity were obtained from the 2001 census. Incidence and prevalence were calculated in each ethnic group. Results showed that in a population of 683,194, of which 22% were of African ancestry, 88 individuals with ALS were identified over a seven-year period, including 14 people with African ancestry. The adjusted incidence in people of African ancestry was 1.35 per 100,000 person-years (95% CI 0.72-2.3) and in those of European ancestry 1.97 per 100,000 person-years (95% CI 1.55-2.48). In conclusion, in this small population based study we could not detect a difference in rates of ALS between people of African ancestry and those of European ancestry.

Original language	English
Pages (from-to)	66 - 68
Number of pages	3
Journal	Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume	13
Issue number	1
DOIs	https://doi.org/10.3109/17482968.2011.636049
Publication status	Published - Jan 2012

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10.3109/17482968.2011.636049

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Rojas-Garcia, R., Scott, K. M., Roche, J. C., Scotton, W., Martin, N., Janssen, A., Goldstein, L. H., Leigh, P. N., Ellis, C. M., Shaw, C. E., & Al-Chalabi, A. (2012). No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 13(1), 66 - 68. https://doi.org/10.3109/17482968.2011.636049

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title = "No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London",

abstract = "Previous studies have suggested a lower incidence of ALS in people of African origin. We used a population based register in an urban setting from inner city London postcodes where there is a large population of people of African ancestry to compare the frequency of ALS in people of European and African origin. Population statistics stratified by age, gender and ethnicity were obtained from the 2001 census. Incidence and prevalence were calculated in each ethnic group. Results showed that in a population of 683,194, of which 22% were of African ancestry, 88 individuals with ALS were identified over a seven-year period, including 14 people with African ancestry. The adjusted incidence in people of African ancestry was 1.35 per 100,000 person-years (95% CI 0.72-2.3) and in those of European ancestry 1.97 per 100,000 person-years (95% CI 1.55-2.48). In conclusion, in this small population based study we could not detect a difference in rates of ALS between people of African ancestry and those of European ancestry.",

author = "Ricardo Rojas-Garcia and Scott, {Kirsten M.} and Roche, {Jose Carlos} and William Scotton and Naomi Martin and Anna Janssen and Goldstein, {Laura H.} and Leigh, {P. Nigel} and Ellis, {Cathy M.} and Shaw, {Christopher E.} and Ammar Al-Chalabi",

year = "2012",

month = jan,

doi = "10.3109/17482968.2011.636049",

language = "English",

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journal = "Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders",

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Rojas-Garcia, R, Scott, KM, Roche, JC, Scotton, W, Martin, N , Janssen, A , Goldstein, LH , Leigh, PN, Ellis, CM, Shaw, CE & Al-Chalabi, A 2012, 'No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London', Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, vol. 13, no. 1, pp. 66 - 68. https://doi.org/10.3109/17482968.2011.636049

No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London. / Rojas-Garcia, Ricardo; Scott, Kirsten M.; Roche, Jose Carlos et al.
In: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, Vol. 13, No. 1, 01.2012, p. 66 - 68.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London

AU - Rojas-Garcia, Ricardo

AU - Scott, Kirsten M.

AU - Roche, Jose Carlos

AU - Scotton, William

AU - Martin, Naomi

AU - Janssen, Anna

AU - Goldstein, Laura H.

AU - Leigh, P. Nigel

AU - Ellis, Cathy M.

AU - Shaw, Christopher E.

AU - Al-Chalabi, Ammar

PY - 2012/1

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N2 - Previous studies have suggested a lower incidence of ALS in people of African origin. We used a population based register in an urban setting from inner city London postcodes where there is a large population of people of African ancestry to compare the frequency of ALS in people of European and African origin. Population statistics stratified by age, gender and ethnicity were obtained from the 2001 census. Incidence and prevalence were calculated in each ethnic group. Results showed that in a population of 683,194, of which 22% were of African ancestry, 88 individuals with ALS were identified over a seven-year period, including 14 people with African ancestry. The adjusted incidence in people of African ancestry was 1.35 per 100,000 person-years (95% CI 0.72-2.3) and in those of European ancestry 1.97 per 100,000 person-years (95% CI 1.55-2.48). In conclusion, in this small population based study we could not detect a difference in rates of ALS between people of African ancestry and those of European ancestry.

AB - Previous studies have suggested a lower incidence of ALS in people of African origin. We used a population based register in an urban setting from inner city London postcodes where there is a large population of people of African ancestry to compare the frequency of ALS in people of European and African origin. Population statistics stratified by age, gender and ethnicity were obtained from the 2001 census. Incidence and prevalence were calculated in each ethnic group. Results showed that in a population of 683,194, of which 22% were of African ancestry, 88 individuals with ALS were identified over a seven-year period, including 14 people with African ancestry. The adjusted incidence in people of African ancestry was 1.35 per 100,000 person-years (95% CI 0.72-2.3) and in those of European ancestry 1.97 per 100,000 person-years (95% CI 1.55-2.48). In conclusion, in this small population based study we could not detect a difference in rates of ALS between people of African ancestry and those of European ancestry.

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DO - 10.3109/17482968.2011.636049

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SN - 2167-9223

SN - 1471-180X

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SP - 66

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JO - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

JF - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

IS - 1

ER -

No evidence for a large difference in ALS frequency in populations of African and European origin: A population based study in inner city London

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