No prospective association between hypotension and idiopathic fatigue

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Objective: To test the hypothesis that there is a prospective association between constitutional hypotension and new-onset fatigue in a large, representative sample. Methods: In this prospective study using a large population-based cohort dataset, the Health and Lifestyle Survey, a representative sample of the population residing in private dwellings in Great Britain in 1984 (n=9003, ages 18-97 years) had their blood pressure measured and were asked about fatigue. Participants reporting fatigue at baseline were excluded. The outcome was fatigue state in 1991. Results: No association was shown, unadjusted or adjusted for likely confounders, in the healthy young population [systolic BP: adj. OR (95% CIs)=1.25 (0.90-1.74); diastolic BP: 1.18 (0.84-1.65)] or the whole population [systolic BP: 0.98 (0.77-1.26); diastolic BP: 1.01 (0.79-1.26)]. Conclusion: In this British population-based study, hypotension was not a risk factor for incident idiopathic fatigue. (C) 2009 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)153 - 158
Number of pages6
JournalJournal of Psychosomatic Research
Issue number2
Publication statusPublished - Aug 2009


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