Non-coding functions of alternative pre-mRNA splicing in development

TY - JOUR

T1 - Non-coding functions of alternative pre-mRNA splicing in development

AU - Mockenhaupt, Stefan

AU - Makeyev, Evgeniy

PY - 2015/12

Y1 - 2015/12

N2 - A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.

AB - A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.

U2 - 10.1016/j.semcdb.2015.10.018

DO - 10.1016/j.semcdb.2015.10.018

M3 - Literature review

SN - 1084-9521

VL - 47-48

SP - 32

EP - 39

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -