Non-invasive brain stimulation for the lower limb after stroke: what do we know so far and what should we be doing next?

Melanie K. Fleming*, Marousa Pavlou, Di J. Newham, Laszlo Sztriha, James T. Teo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Non-invasive brain stimulation (NIBS) is promising as an adjuvant to rehabilitation of motor function after stroke. Despite numerous studies and reviews for the upper limb, NIBS targeting the lower limb and gait recovery after stroke is a newly emerging field of research. Purpose: To summarize findings from studies using NIBS to target the lower limb in stroke survivors. Methods: This narrative review describes studies of repetitive transcranial magnetic stimulation, paired associative stimulation and transcranial direct current stimulation with survivors of stroke. Results: NIBS appears capable of inducing changes in cortical excitability and lower limb function, but stimulation parameters and study designs vary considerably making it difficult to determine effectiveness. Conclusions: Future research should systematically assess differences in response with different stimulation parameters, test measures for determining who would be most likely to benefit and assess effectiveness with large samples before NIBS can be considered for use in clinical practice.Implications for RehabilitationStroke is a leading cause of disability, often resulting in dependency in activities of daily living and reduced quality of life.Non-invasive brain stimulation has received considerable interest as a potential adjuvant to rehabilitation after stroke and this review summarizes studies targeting the lower limb and gait recovery.Non-invasive brain stimulation can be used to modulate excitability of lower limb muscle representations and can lead to improvements in motor performance in stroke survivors.Non-invasive brain stimulation for gait recovery needs further investigation before translation to clinical practice is possible.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalDisability and Rehabilitation
Early online date25 Mar 2016
Publication statusE-pub ahead of print - 25 Mar 2016


  • Gait
  • stroke
  • transcranial direct current stimulation
  • transcranial magnetic stimulation


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