Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents

Tobias C Wood; Diana Cash; Eilidh MacNicol; Camilla Simmons; Eugene Kim; David J Lythgoe; Fernando Zelaya; Federico Turkheimer

doi:10.12688/wellcomeopenres.16734.1

Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents

Tobias C Wood, Diana Cash, Eilidh MacNicol, Camilla Simmons, Eugene Kim, David J Lythgoe, Fernando Zelaya, Federico Turkheimer

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Abstract

Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO 2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.

Original language	English
Pages (from-to)	109
Journal	Wellcome Open Research
Volume	6
DOIs	https://doi.org/10.12688/wellcomeopenres.16734.1
Publication status	Published - 25 Aug 2022

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Non-Invasive measurement of_WOOD_Publishedonline25August2022_GOLD VoR (CC BY)Final published version, 3.93 MBLicence: CC BY

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AU - Lythgoe, David J

AU - Zelaya, Fernando

AU - Turkheimer, Federico

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AB - Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO 2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.

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Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents

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