Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents

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Abstract

Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO 2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.

Original languageEnglish
Pages (from-to)109
JournalWellcome Open Research
Volume6
DOIs
Publication statusPublished - 25 Aug 2022

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