Non-invasive pressure difference estimation from PC-MRI using the work-energy equation

Fabrizio Donati; C. Alberto Figueroa; Nicolas P. Smith; Pablo Lamata de la Orden; David A. Nordsletten

doi:10.1016/j.media.2015.08.012

Non-invasive pressure difference estimation from PC-MRI using the work-energy equation

Fabrizio Donati^*, C. Alberto Figueroa, Nicolas P. Smith, Pablo Lamata de la Orden, David A. Nordsletten

^*Corresponding author for this work

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

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Abstract

Pressure difference is an accepted clinical biomarker for cardiovascular disease conditions such as aortic coarctation. Currently, measurements of pressure differences in the clinic rely on invasive techniques (catheterization), prompting development of non-invasive estimates based on blood flow. In this work, we propose a non-invasive estimation procedure deriving pressure difference from the work-energy equation for a Newtonian fluid. Spatial and temporal convergence is demonstrated on in silico Phase Contrast Magnetic Resonance Image (PC-MRI) phantoms with steady and transient flow fields. The method is also tested on an image dataset generated in silico from a 3D patient-specific Computational Fluid Dynamics (CFD) simulation and finally evaluated on a cohort of 9 subjects. The performance is compared to existing approaches based on steady and unsteady Bernoulli formulations as well as the pressure Poisson equation. The new technique shows good accuracy, robustness to noise, and robustness to the image segmentation process, illustrating the potential of this approach for non-invasive pressure difference estimation.

Original language	English
Pages (from-to)	159-172
Number of pages	14
Journal	Medical Image Analysis
Volume	26
Issue number	1
Early online date	8 Sept 2015
DOIs	https://doi.org/10.1016/j.media.2015.08.012
Publication status	Published - 1 Dec 2015

Keywords

4D flow
Aortic flow
PC-MRI
Pressure differences estimation
Work-energy equation

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Non-invasive pressure difference_DONATI_Publishedonline8September2015_GOLD VoR (CC BY)Final published version, 1.81 MBLicence: CC BY

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title = "Non-invasive pressure difference estimation from PC-MRI using the work-energy equation",

abstract = "Pressure difference is an accepted clinical biomarker for cardiovascular disease conditions such as aortic coarctation. Currently, measurements of pressure differences in the clinic rely on invasive techniques (catheterization), prompting development of non-invasive estimates based on blood flow. In this work, we propose a non-invasive estimation procedure deriving pressure difference from the work-energy equation for a Newtonian fluid. Spatial and temporal convergence is demonstrated on in silico Phase Contrast Magnetic Resonance Image (PC-MRI) phantoms with steady and transient flow fields. The method is also tested on an image dataset generated in silico from a 3D patient-specific Computational Fluid Dynamics (CFD) simulation and finally evaluated on a cohort of 9 subjects. The performance is compared to existing approaches based on steady and unsteady Bernoulli formulations as well as the pressure Poisson equation. The new technique shows good accuracy, robustness to noise, and robustness to the image segmentation process, illustrating the potential of this approach for non-invasive pressure difference estimation.",

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AU - Donati, Fabrizio

AU - Figueroa, C. Alberto

AU - Smith, Nicolas P.

AU - Lamata de la Orden, Pablo

AU - Nordsletten, David A.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Pressure difference is an accepted clinical biomarker for cardiovascular disease conditions such as aortic coarctation. Currently, measurements of pressure differences in the clinic rely on invasive techniques (catheterization), prompting development of non-invasive estimates based on blood flow. In this work, we propose a non-invasive estimation procedure deriving pressure difference from the work-energy equation for a Newtonian fluid. Spatial and temporal convergence is demonstrated on in silico Phase Contrast Magnetic Resonance Image (PC-MRI) phantoms with steady and transient flow fields. The method is also tested on an image dataset generated in silico from a 3D patient-specific Computational Fluid Dynamics (CFD) simulation and finally evaluated on a cohort of 9 subjects. The performance is compared to existing approaches based on steady and unsteady Bernoulli formulations as well as the pressure Poisson equation. The new technique shows good accuracy, robustness to noise, and robustness to the image segmentation process, illustrating the potential of this approach for non-invasive pressure difference estimation.

AB - Pressure difference is an accepted clinical biomarker for cardiovascular disease conditions such as aortic coarctation. Currently, measurements of pressure differences in the clinic rely on invasive techniques (catheterization), prompting development of non-invasive estimates based on blood flow. In this work, we propose a non-invasive estimation procedure deriving pressure difference from the work-energy equation for a Newtonian fluid. Spatial and temporal convergence is demonstrated on in silico Phase Contrast Magnetic Resonance Image (PC-MRI) phantoms with steady and transient flow fields. The method is also tested on an image dataset generated in silico from a 3D patient-specific Computational Fluid Dynamics (CFD) simulation and finally evaluated on a cohort of 9 subjects. The performance is compared to existing approaches based on steady and unsteady Bernoulli formulations as well as the pressure Poisson equation. The new technique shows good accuracy, robustness to noise, and robustness to the image segmentation process, illustrating the potential of this approach for non-invasive pressure difference estimation.

KW - 4D flow

KW - Aortic flow

KW - PC-MRI

KW - Pressure differences estimation

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Non-invasive pressure difference estimation from PC-MRI using the work-energy equation

Abstract

Keywords

UN SDGs

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