Non-ischaemic Dilated Cardiomyopathy

Andrea Barison; Stefano Figliozzi; Pier Giorgio Masci; Gianfranco Sinagra

doi:10.1007/978-3-031-32593-9_5

Non-ischaemic Dilated Cardiomyopathy

Andrea Barison^*, Stefano Figliozzi, Pier Giorgio Masci^*, Gianfranco Sinagra^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Dilated cardiomyopathy (DCM) is a common clinical condition characterized by left ventricular dilation and dysfunction in the absence of ischaemic heart disease or pressure/volume overload. Despite considerable advances in the treatment of heart failure, the mortality rate of this disorder remains not negligible and is mainly due to sudden cardiac death and pump dysfunction. In the last years, it has been demonstrated that patients affected by DCM might be quite different in terms of underlying aetiology and, consequently, prognosis and response to treatment. In parallel, it has become more critical to dispose of instruments able to provide detailed insights regarding the aetiology and phenotype of DCM patients to individualize patient management and improve long-term outcomes. Cardiovascular magnetic resonance (CMR) has become increasingly accessible in the clinical arena and is considered the gold standard for the assessment of biventricular volumes and function. Moreover, multiparametric sequences allow tissue characterization including the presence and distribution of scar with late enhancement imaging, myocardial oedema with T2-weighted imaging, and myocardial perfusion with first-pass sequences, offering the clinician an accurate aetiological and prognostic characterization of DCM patients. Recently, native T1 mapping, T2 mapping and extracellular volume mapping have been introduced as quantitative tools, further improving the diagnostic and prognostic usefulness of CMR. These obvious advantages explain why CMR has emerged as the ideal imaging modality assessing DCM patients after a first-level examination, including clinical, biohumoral, electrocardiography and echocardiography. After an introductive section elucidating an up-to-date perspective on the multiple potentials of CMR imaging of DCM patients, ten cases are shown to highlight the practical role of CMR in guiding diagnosis, prognosis and tailoring therapeutic options in DCM.

Original language	English
Title of host publication	Case-based Atlas of Cardiovascular Magnetic Resonance
Publisher	Springer International Publishing
Pages	83-102
Number of pages	20
ISBN (Electronic)	9783031325939
ISBN (Print)	9783031325922
DOIs	https://doi.org/10.1007/978-3-031-32593-9_5
Publication status	Published - 1 Jan 2023

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10.1007/978-3-031-32593-9_5

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abstract = "Dilated cardiomyopathy (DCM) is a common clinical condition characterized by left ventricular dilation and dysfunction in the absence of ischaemic heart disease or pressure/volume overload. Despite considerable advances in the treatment of heart failure, the mortality rate of this disorder remains not negligible and is mainly due to sudden cardiac death and pump dysfunction. In the last years, it has been demonstrated that patients affected by DCM might be quite different in terms of underlying aetiology and, consequently, prognosis and response to treatment. In parallel, it has become more critical to dispose of instruments able to provide detailed insights regarding the aetiology and phenotype of DCM patients to individualize patient management and improve long-term outcomes. Cardiovascular magnetic resonance (CMR) has become increasingly accessible in the clinical arena and is considered the gold standard for the assessment of biventricular volumes and function. Moreover, multiparametric sequences allow tissue characterization including the presence and distribution of scar with late enhancement imaging, myocardial oedema with T2-weighted imaging, and myocardial perfusion with first-pass sequences, offering the clinician an accurate aetiological and prognostic characterization of DCM patients. Recently, native T1 mapping, T2 mapping and extracellular volume mapping have been introduced as quantitative tools, further improving the diagnostic and prognostic usefulness of CMR. These obvious advantages explain why CMR has emerged as the ideal imaging modality assessing DCM patients after a first-level examination, including clinical, biohumoral, electrocardiography and echocardiography. After an introductive section elucidating an up-to-date perspective on the multiple potentials of CMR imaging of DCM patients, ten cases are shown to highlight the practical role of CMR in guiding diagnosis, prognosis and tailoring therapeutic options in DCM.",

author = "Andrea Barison and Stefano Figliozzi and Masci, {Pier Giorgio} and Gianfranco Sinagra",

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AU - Sinagra, Gianfranco

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N2 - Dilated cardiomyopathy (DCM) is a common clinical condition characterized by left ventricular dilation and dysfunction in the absence of ischaemic heart disease or pressure/volume overload. Despite considerable advances in the treatment of heart failure, the mortality rate of this disorder remains not negligible and is mainly due to sudden cardiac death and pump dysfunction. In the last years, it has been demonstrated that patients affected by DCM might be quite different in terms of underlying aetiology and, consequently, prognosis and response to treatment. In parallel, it has become more critical to dispose of instruments able to provide detailed insights regarding the aetiology and phenotype of DCM patients to individualize patient management and improve long-term outcomes. Cardiovascular magnetic resonance (CMR) has become increasingly accessible in the clinical arena and is considered the gold standard for the assessment of biventricular volumes and function. Moreover, multiparametric sequences allow tissue characterization including the presence and distribution of scar with late enhancement imaging, myocardial oedema with T2-weighted imaging, and myocardial perfusion with first-pass sequences, offering the clinician an accurate aetiological and prognostic characterization of DCM patients. Recently, native T1 mapping, T2 mapping and extracellular volume mapping have been introduced as quantitative tools, further improving the diagnostic and prognostic usefulness of CMR. These obvious advantages explain why CMR has emerged as the ideal imaging modality assessing DCM patients after a first-level examination, including clinical, biohumoral, electrocardiography and echocardiography. After an introductive section elucidating an up-to-date perspective on the multiple potentials of CMR imaging of DCM patients, ten cases are shown to highlight the practical role of CMR in guiding diagnosis, prognosis and tailoring therapeutic options in DCM.

AB - Dilated cardiomyopathy (DCM) is a common clinical condition characterized by left ventricular dilation and dysfunction in the absence of ischaemic heart disease or pressure/volume overload. Despite considerable advances in the treatment of heart failure, the mortality rate of this disorder remains not negligible and is mainly due to sudden cardiac death and pump dysfunction. In the last years, it has been demonstrated that patients affected by DCM might be quite different in terms of underlying aetiology and, consequently, prognosis and response to treatment. In parallel, it has become more critical to dispose of instruments able to provide detailed insights regarding the aetiology and phenotype of DCM patients to individualize patient management and improve long-term outcomes. Cardiovascular magnetic resonance (CMR) has become increasingly accessible in the clinical arena and is considered the gold standard for the assessment of biventricular volumes and function. Moreover, multiparametric sequences allow tissue characterization including the presence and distribution of scar with late enhancement imaging, myocardial oedema with T2-weighted imaging, and myocardial perfusion with first-pass sequences, offering the clinician an accurate aetiological and prognostic characterization of DCM patients. Recently, native T1 mapping, T2 mapping and extracellular volume mapping have been introduced as quantitative tools, further improving the diagnostic and prognostic usefulness of CMR. These obvious advantages explain why CMR has emerged as the ideal imaging modality assessing DCM patients after a first-level examination, including clinical, biohumoral, electrocardiography and echocardiography. After an introductive section elucidating an up-to-date perspective on the multiple potentials of CMR imaging of DCM patients, ten cases are shown to highlight the practical role of CMR in guiding diagnosis, prognosis and tailoring therapeutic options in DCM.

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ER -

Non-ischaemic Dilated Cardiomyopathy

Abstract

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