Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?

Sarah Kittel-Schneider; Gara Arteaga-Henriquez; Alejandro Arias Vasquez; Phil Asherson; Tobias Banaschewski; Isabell Brikell; Jan Buitelaar; Bru Cormand; Stephen V. Faraone; Christine M. Freitag; Ylva Ginsberg; Jan Haavik; Catharina A. Hartman; Jonna Kuntsi; Henrik Larsson; Silke Matura; Rhiannon V. McNeill; J. Antoni Ramos-Quiroga; Marta Ribases; Marcel Romanos; Isabella Vainieri; Barbara Franke; Andreas Reif

doi:10.1016/j.neubiorev.2021.10.035

Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?

Sarah Kittel-Schneider^*
, Gara Arteaga-Henriquez
, Alejandro Arias Vasquez
, Phil Asherson
, Tobias Banaschewski
, Isabell Brikell
, Jan Buitelaar
, Bru Cormand
, Stephen V. Faraone
, Christine M. Freitag
, Ylva Ginsberg
, Jan Haavik
, Catharina A. Hartman
, Jonna Kuntsi
, Henrik Larsson
, Silke Matura
, Rhiannon V. McNeill
, J. Antoni Ramos-Quiroga
, Marta Ribases
, Marcel Romanos

Isabella Vainieri, Barbara Franke, Andreas Reif

^*Corresponding author for this work

University Hospital of Würzburg
Goethe University Frankfurt Hospital
Vall d'Hebron University Hospital
Universitat Autònoma de Barcelona
Centre for Biomedical Research on Mental Health (CIBERSAM)
Donders Institute for Brain, Cognition and Behaviour
Department of Neurology
King's College London
Heidelberg University
Aarhus University
Lundbeck Foundation
Karolinska Institute
Karakter Child and Adolescent Psychiatry University Center
University of Barcelona
CIBER - Centro de Investigacion Biomedica en Red
Institut de Recerca Sant Joan de Déu
SUNY Upstate Medical University
Haukeland University Hospital
University of Bergen
University Medical Center Groningen
Örebro University

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms, genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals.

Original language	English
Journal	Neuroscience and Biobehavioral Reviews
Early online date	29 Oct 2021
DOIs	https://doi.org/10.1016/j.neubiorev.2021.10.035
Publication status	E-pub ahead of print - 29 Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Asthma
Attention-deficit/hyperactivity disorder
Diabetes mellitus type II
Elimination disorders
Epilepsy
Migraine
Non-mental disease
Obesity
Somatic disorders

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10.1016/j.neubiorev.2021.10.035

Cite this

Kittel-Schneider, S., Arteaga-Henriquez, G., Vasquez, A. A., Asherson, P., Banaschewski, T., Brikell, I., Buitelaar, J., Cormand, B., Faraone, S. V., Freitag, C. M., Ginsberg, Y., Haavik, J., Hartman, C. A., Kuntsi, J., Larsson, H., Matura, S., McNeill, R. V., Ramos-Quiroga, J. A., Ribases, M., ... Reif, A. (2021). Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity? Neuroscience and Biobehavioral Reviews. Advance online publication. https://doi.org/10.1016/j.neubiorev.2021.10.035

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title = "Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?",

abstract = "Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms, genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals.",

keywords = "Asthma, Attention-deficit/hyperactivity disorder, Diabetes mellitus type II, Elimination disorders, Epilepsy, Migraine, Non-mental disease, Obesity, Somatic disorders",

author = "Sarah Kittel-Schneider and Gara Arteaga-Henriquez and Vasquez, \{Alejandro Arias\} and Phil Asherson and Tobias Banaschewski and Isabell Brikell and Jan Buitelaar and Bru Cormand and Faraone, \{Stephen V.\} and Freitag, \{Christine M.\} and Ylva Ginsberg and Jan Haavik and Hartman, \{Catharina A.\} and Jonna Kuntsi and Henrik Larsson and Silke Matura and McNeill, \{Rhiannon V.\} and Ramos-Quiroga, \{J. Antoni\} and Marta Ribases and Marcel Romanos and Isabella Vainieri and Barbara Franke and Andreas Reif",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = oct,

day = "29",

doi = "10.1016/j.neubiorev.2021.10.035",

language = "English",

journal = "Neuroscience and Biobehavioral Reviews",

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Kittel-Schneider, S, Arteaga-Henriquez, G, Vasquez, AA, Asherson, P, Banaschewski, T, Brikell, I, Buitelaar, J, Cormand, B, Faraone, SV, Freitag, CM, Ginsberg, Y, Haavik, J, Hartman, CA, Kuntsi, J, Larsson, H, Matura, S, McNeill, RV, Ramos-Quiroga, JA, Ribases, M, Romanos, M, Vainieri, I, Franke, B & Reif, A 2021, 'Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?', Neuroscience and Biobehavioral Reviews. https://doi.org/10.1016/j.neubiorev.2021.10.035

TY - JOUR

T1 - Non-mental diseases associated with ADHD across the lifespan

T2 - Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?

AU - Kittel-Schneider, Sarah

AU - Arteaga-Henriquez, Gara

AU - Vasquez, Alejandro Arias

AU - Asherson, Phil

AU - Banaschewski, Tobias

AU - Brikell, Isabell

AU - Buitelaar, Jan

AU - Cormand, Bru

AU - Faraone, Stephen V.

AU - Freitag, Christine M.

AU - Ginsberg, Ylva

AU - Haavik, Jan

AU - Hartman, Catharina A.

AU - Kuntsi, Jonna

AU - Larsson, Henrik

AU - Matura, Silke

AU - McNeill, Rhiannon V.

AU - Ramos-Quiroga, J. Antoni

AU - Ribases, Marta

AU - Romanos, Marcel

AU - Vainieri, Isabella

AU - Franke, Barbara

AU - Reif, Andreas

PY - 2021/10/29

Y1 - 2021/10/29

N2 - Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms, genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals.

AB - Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms, genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals.

KW - Asthma

KW - Attention-deficit/hyperactivity disorder

KW - Diabetes mellitus type II

KW - Elimination disorders

KW - Epilepsy

KW - Migraine

KW - Non-mental disease

KW - Obesity

KW - Somatic disorders

UR - https://www.scopus.com/pages/publications/85119174678

U2 - 10.1016/j.neubiorev.2021.10.035

DO - 10.1016/j.neubiorev.2021.10.035

M3 - Article

AN - SCOPUS:85119174678

SN - 0149-7634

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?

Abstract

UN SDGs

Keywords

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