Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA

TY - JOUR

T1 - Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA

AU - Giacca, Mauro

PY - 2010/1/1

Y1 - 2010/1/1

N2 - The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.

AB - The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.

KW - Alternative splicing

KW - Angiogenesis

KW - Cancer

KW - Neuropilin-1

KW - Transcription

KW - Vascular endothelial growth factor

UR - http://www.scopus.com/inward/record.url?scp=79952269928&partnerID=8YFLogxK

U2 - 10.4161/trns.1.3.13229

DO - 10.4161/trns.1.3.13229

M3 - Article

AN - SCOPUS:79952269928

SN - 2154-1264

VL - 1

SP - 149

EP - 153

JO - Transcription

JF - Transcription

IS - 3

ER -