Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting

Martin Georg Zeilinger; Karl Philipp Kunze; Camila Munoz; Radhouene Neji; Michaela Schmidt; Pierre Croisille; Rafael Heiss; Wolfgang Wuest; Michael Uder; René Michael Botnar; Christoph Treutlein; Claudia Prieto

doi:10.1007/s00330-022-08560-6

Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting

Martin Georg Zeilinger^*, Karl Philipp Kunze, Camila Munoz, Radhouene Neji, Michaela Schmidt, Pierre Croisille, Rafael Heiss, Wolfgang Wuest, Michael Uder, René Michael Botnar, Christoph Treutlein, Claudia Prieto

^*Corresponding author for this work

Biomedical Engineering Department

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Abstract

Objectives: To investigate the efficacy of an in-line non-rigid motion-compensated reconstruction (NRC) in an image-navigated high-resolution three-dimensional late gadolinium enhancement (LGE) sequence with Dixon water–fat separation, in a clinical setting. Methods: Forty-seven consecutive patients were enrolled prospectively and examined with 1.5 T MRI. NRC reconstructions were compared to translational motion-compensated reconstructions (TC) of the same datasets in overall and different sub-category image quality scores, diagnostic confidence, contrast ratios, LGE pattern, and semiautomatic LGE quantification. Results: NRC outperformed TC in all image quality scores (p < 0.001 to 0.016; e.g., overall image quality 5/5 points vs. 4/5). Overall image quality was downgraded in only 23% of NRC datasets vs. 53% of TC datasets due to residual respiratory motion. In both reconstructions, LGE was rated as ischemic in 11 patients and non-ischemic in 10 patients, while it was absent in 26 patients. NRC delivered significantly higher LGE-to-myocardium and blood-to-myocardium contrast ratios (median 6.33 vs. 5.96, p < 0.001 and 4.88 vs. 4.66, p < 0.001, respectively). Automatically detected LGE mass was significantly lower in the NRC reconstruction (p < 0.001). Diagnostic confidence was identical in all cases, with high confidence in 89% and probable in 11% datasets for both reconstructions. No case was rated as inconclusive. Conclusions: The in-line implementation of a non-rigid motion-compensated reconstruction framework improved image quality in image-navigated free-breathing, isotropic high-resolution 3D LGE imaging with undersampled spiral-like Cartesian sampling and Dixon water–fat separation compared to translational motion correction of the same datasets. The sharper depictions of LGE may lead to more accurate measures of LGE mass. Key Points: • 3D LGE imaging provides high-resolution detection of myocardial scarring. • Non-rigid motion correction provides better image quality in cardiac MRI. • Non-rigid motion correction may lead to more accurate measures of LGE mass.

Original language	English
Pages (from-to)	4340-4351
Number of pages	12
Journal	European Radiology
Volume	32
Issue number	7
Early online date	20 Feb 2022
DOIs	https://doi.org/10.1007/s00330-022-08560-6
Publication status	Published - Jul 2022

Keywords

Heart
Magnetic resonance imaging
Myocardium
Three-dimensional imaging

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@article{035ad924ec614e8f8e8c47f46cfa621b,

title = "Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting",

abstract = "Objectives: To investigate the efficacy of an in-line non-rigid motion-compensated reconstruction (NRC) in an image-navigated high-resolution three-dimensional late gadolinium enhancement (LGE) sequence with Dixon water–fat separation, in a clinical setting. Methods: Forty-seven consecutive patients were enrolled prospectively and examined with 1.5 T MRI. NRC reconstructions were compared to translational motion-compensated reconstructions (TC) of the same datasets in overall and different sub-category image quality scores, diagnostic confidence, contrast ratios, LGE pattern, and semiautomatic LGE quantification. Results: NRC outperformed TC in all image quality scores (p < 0.001 to 0.016; e.g., overall image quality 5/5 points vs. 4/5). Overall image quality was downgraded in only 23% of NRC datasets vs. 53% of TC datasets due to residual respiratory motion. In both reconstructions, LGE was rated as ischemic in 11 patients and non-ischemic in 10 patients, while it was absent in 26 patients. NRC delivered significantly higher LGE-to-myocardium and blood-to-myocardium contrast ratios (median 6.33 vs. 5.96, p < 0.001 and 4.88 vs. 4.66, p < 0.001, respectively). Automatically detected LGE mass was significantly lower in the NRC reconstruction (p < 0.001). Diagnostic confidence was identical in all cases, with high confidence in 89% and probable in 11% datasets for both reconstructions. No case was rated as inconclusive. Conclusions: The in-line implementation of a non-rigid motion-compensated reconstruction framework improved image quality in image-navigated free-breathing, isotropic high-resolution 3D LGE imaging with undersampled spiral-like Cartesian sampling and Dixon water–fat separation compared to translational motion correction of the same datasets. The sharper depictions of LGE may lead to more accurate measures of LGE mass. Key Points: • 3D LGE imaging provides high-resolution detection of myocardial scarring. • Non-rigid motion correction provides better image quality in cardiac MRI. • Non-rigid motion correction may lead to more accurate measures of LGE mass.",

keywords = "Heart, Magnetic resonance imaging, Myocardium, Three-dimensional imaging",

author = "Zeilinger, {Martin Georg} and Kunze, {Karl Philipp} and Camila Munoz and Radhouene Neji and Michaela Schmidt and Pierre Croisille and Rafael Heiss and Wolfgang Wuest and Michael Uder and Botnar, {Ren{\'e} Michael} and Christoph Treutlein and Claudia Prieto",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jul,

doi = "10.1007/s00330-022-08560-6",

language = "English",

volume = "32",

pages = "4340--4351",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

number = "7",

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TY - JOUR

T1 - Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting

AU - Zeilinger, Martin Georg

AU - Kunze, Karl Philipp

AU - Munoz, Camila

AU - Neji, Radhouene

AU - Schmidt, Michaela

AU - Croisille, Pierre

AU - Heiss, Rafael

AU - Wuest, Wolfgang

AU - Uder, Michael

AU - Botnar, René Michael

AU - Treutlein, Christoph

AU - Prieto, Claudia

PY - 2022/7

Y1 - 2022/7

N2 - Objectives: To investigate the efficacy of an in-line non-rigid motion-compensated reconstruction (NRC) in an image-navigated high-resolution three-dimensional late gadolinium enhancement (LGE) sequence with Dixon water–fat separation, in a clinical setting. Methods: Forty-seven consecutive patients were enrolled prospectively and examined with 1.5 T MRI. NRC reconstructions were compared to translational motion-compensated reconstructions (TC) of the same datasets in overall and different sub-category image quality scores, diagnostic confidence, contrast ratios, LGE pattern, and semiautomatic LGE quantification. Results: NRC outperformed TC in all image quality scores (p < 0.001 to 0.016; e.g., overall image quality 5/5 points vs. 4/5). Overall image quality was downgraded in only 23% of NRC datasets vs. 53% of TC datasets due to residual respiratory motion. In both reconstructions, LGE was rated as ischemic in 11 patients and non-ischemic in 10 patients, while it was absent in 26 patients. NRC delivered significantly higher LGE-to-myocardium and blood-to-myocardium contrast ratios (median 6.33 vs. 5.96, p < 0.001 and 4.88 vs. 4.66, p < 0.001, respectively). Automatically detected LGE mass was significantly lower in the NRC reconstruction (p < 0.001). Diagnostic confidence was identical in all cases, with high confidence in 89% and probable in 11% datasets for both reconstructions. No case was rated as inconclusive. Conclusions: The in-line implementation of a non-rigid motion-compensated reconstruction framework improved image quality in image-navigated free-breathing, isotropic high-resolution 3D LGE imaging with undersampled spiral-like Cartesian sampling and Dixon water–fat separation compared to translational motion correction of the same datasets. The sharper depictions of LGE may lead to more accurate measures of LGE mass. Key Points: • 3D LGE imaging provides high-resolution detection of myocardial scarring. • Non-rigid motion correction provides better image quality in cardiac MRI. • Non-rigid motion correction may lead to more accurate measures of LGE mass.

AB - Objectives: To investigate the efficacy of an in-line non-rigid motion-compensated reconstruction (NRC) in an image-navigated high-resolution three-dimensional late gadolinium enhancement (LGE) sequence with Dixon water–fat separation, in a clinical setting. Methods: Forty-seven consecutive patients were enrolled prospectively and examined with 1.5 T MRI. NRC reconstructions were compared to translational motion-compensated reconstructions (TC) of the same datasets in overall and different sub-category image quality scores, diagnostic confidence, contrast ratios, LGE pattern, and semiautomatic LGE quantification. Results: NRC outperformed TC in all image quality scores (p < 0.001 to 0.016; e.g., overall image quality 5/5 points vs. 4/5). Overall image quality was downgraded in only 23% of NRC datasets vs. 53% of TC datasets due to residual respiratory motion. In both reconstructions, LGE was rated as ischemic in 11 patients and non-ischemic in 10 patients, while it was absent in 26 patients. NRC delivered significantly higher LGE-to-myocardium and blood-to-myocardium contrast ratios (median 6.33 vs. 5.96, p < 0.001 and 4.88 vs. 4.66, p < 0.001, respectively). Automatically detected LGE mass was significantly lower in the NRC reconstruction (p < 0.001). Diagnostic confidence was identical in all cases, with high confidence in 89% and probable in 11% datasets for both reconstructions. No case was rated as inconclusive. Conclusions: The in-line implementation of a non-rigid motion-compensated reconstruction framework improved image quality in image-navigated free-breathing, isotropic high-resolution 3D LGE imaging with undersampled spiral-like Cartesian sampling and Dixon water–fat separation compared to translational motion correction of the same datasets. The sharper depictions of LGE may lead to more accurate measures of LGE mass. Key Points: • 3D LGE imaging provides high-resolution detection of myocardial scarring. • Non-rigid motion correction provides better image quality in cardiac MRI. • Non-rigid motion correction may lead to more accurate measures of LGE mass.

KW - Heart

KW - Magnetic resonance imaging

KW - Myocardium

KW - Three-dimensional imaging

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U2 - 10.1007/s00330-022-08560-6

DO - 10.1007/s00330-022-08560-6

M3 - Article

AN - SCOPUS:85124722957

SN - 0938-7994

VL - 32

SP - 4340

EP - 4351

JO - European Radiology

JF - European Radiology

IS - 7

ER -

Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting

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