Non-traditional roles of G protein-coupled receptors in basic cell biology

TY - JOUR

T1 - Non-traditional roles of G protein-coupled receptors in basic cell biology

AU - Zhang, Xin

AU - Eggert, Ulrike S

PY - 2013/4/5

Y1 - 2013/4/5

N2 - G protein-coupled receptors (GPCRs) are key signaling proteins that regulate how cells interact with their environment. Traditional signaling cascades involving GPCRs have been well described and are well established and very important clinical targets. With the development of more recent technologies, hints about the involvement of GPCRs in fundamental cell biological processes are beginning to emerge. In this review, we give a basic introduction to GPCR signaling and highlight some less well described roles of GPCRs, including in cell division and membrane trafficking, which may occur through canonical and non-canonical signaling pathways.

AB - G protein-coupled receptors (GPCRs) are key signaling proteins that regulate how cells interact with their environment. Traditional signaling cascades involving GPCRs have been well described and are well established and very important clinical targets. With the development of more recent technologies, hints about the involvement of GPCRs in fundamental cell biological processes are beginning to emerge. In this review, we give a basic introduction to GPCR signaling and highlight some less well described roles of GPCRs, including in cell division and membrane trafficking, which may occur through canonical and non-canonical signaling pathways.

KW - Animals

KW - Cell Division

KW - Cell Membrane

KW - Humans

KW - Protein Transport

KW - Receptors, G-Protein-Coupled

KW - Signal Transduction

U2 - 10.1039/c2mb25429h

DO - 10.1039/c2mb25429h

M3 - Article

C2 - 23247090

SN - 1742-206X

VL - 9

SP - 586

EP - 595

JO - Molecular Biosystems

JF - Molecular Biosystems

IS - 4

M1 - N/A

ER -