TY - JOUR
T1 - Noncanonical Ion Channel Behaviour in Pain
AU - Ciotu, Cosmin I.
AU - Tsantoulas, Christoforos
AU - Meents, Jannis
AU - Lampert, Angelika
AU - McMahon, Stephen B.
AU - Ludwig, Andreas
AU - Fischer, Michael J.M.
PY - 2019/9/15
Y1 - 2019/9/15
N2 - Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Primarily considering ion channels involved in the nociceptive system, this review covers more novel and less known features. Accordingly, we outline noncanonical operation of voltage-gated sodium, potassium, transient receptor potential (TRP), and hyperpolarization-activated cyclic nucleotide (HCN)-gated channels. Noncanonical features discussed include properties as a memory for prior voltage and chemical exposure, alternative ion conduction pathways, cluster formation, and silent subunits. Complementary to this main focus, the intention is also to transfer knowledge between fields, which become inevitably more separate due to their size.
AB - Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Primarily considering ion channels involved in the nociceptive system, this review covers more novel and less known features. Accordingly, we outline noncanonical operation of voltage-gated sodium, potassium, transient receptor potential (TRP), and hyperpolarization-activated cyclic nucleotide (HCN)-gated channels. Noncanonical features discussed include properties as a memory for prior voltage and chemical exposure, alternative ion conduction pathways, cluster formation, and silent subunits. Complementary to this main focus, the intention is also to transfer knowledge between fields, which become inevitably more separate due to their size.
KW - Drug development
KW - HCN channel
KW - Pharmacology
KW - Potassium channel
KW - Sodium channel
KW - TRP channel
UR - http://www.scopus.com/inward/record.url?scp=85072538098&partnerID=8YFLogxK
U2 - 10.3390/ijms20184572
DO - 10.3390/ijms20184572
M3 - Review article
C2 - 31540178
AN - SCOPUS:85072538098
SN - 1661-6596
VL - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 18
M1 - 4572
ER -