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Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times

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Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times. / Pereira, Helder; Jackson, Tom A.; Sieniewicz, Benjamin; Gould, Justin; Yao, Cheng; Niederer, Steven; Rinaldi, Christopher A.

In: Journal of Electrocardiology, Vol. 51, No. 4, 01.07.2018, p. 714-719.

Research output: Contribution to journalArticle

Harvard

Pereira, H, Jackson, TA, Sieniewicz, B, Gould, J, Yao, C, Niederer, S & Rinaldi, CA 2018, 'Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times', Journal of Electrocardiology, vol. 51, no. 4, pp. 714-719. https://doi.org/10.1016/j.jelectrocard.2018.05.006

APA

Pereira, H., Jackson, T. A., Sieniewicz, B., Gould, J., Yao, C., Niederer, S., & Rinaldi, C. A. (2018). Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times. Journal of Electrocardiology, 51(4), 714-719. https://doi.org/10.1016/j.jelectrocard.2018.05.006

Vancouver

Pereira H, Jackson TA, Sieniewicz B, Gould J, Yao C, Niederer S et al. Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times. Journal of Electrocardiology. 2018 Jul 1;51(4):714-719. https://doi.org/10.1016/j.jelectrocard.2018.05.006

Author

Pereira, Helder ; Jackson, Tom A. ; Sieniewicz, Benjamin ; Gould, Justin ; Yao, Cheng ; Niederer, Steven ; Rinaldi, Christopher A. / Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times. In: Journal of Electrocardiology. 2018 ; Vol. 51, No. 4. pp. 714-719.

Bibtex Download

@article{1fcf67853a5341fd96ea23c253d61e06,
title = "Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times",
abstract = "Background Cardiac resynchronization therapy (CRT) is now generally delivered via quadripolar leads. Assessment of the effect of different vector programs from quadripolar leads on ventricular activation can be now done using non-invasive electrocardiographic mapping (ECM). Material and methods In nineteen patients with quadripolar LV leads, activation maps were constructed. The total ventricular activation time (TVaT) and the time for the bulk of ventricular activation (VaT10–90) were calculated. Results CRT delivered via a quadripolar lead significantly reduced TVaT and VaT10–90 by a mean of 16 ms and 31 ms, respectively, compared to baseline. There was a marked reduction in ventricular activation between the most and least synchronous vectors: 28{\%} difference in baseline TVaT and 37{\%} difference in VaT10–90. Conclusion Changes in the configuration of an LV quadripolar lead significantly affected ventricular activation timings in both ischaemic and non-ischaemic subjects. This suggests that programming of the optimal pacing vector may need to be individually tailored.",
keywords = "Cardiac resynchronization therapy, Non-invasive electrocardiographic mapping, Quadripolar left ventricular lead, Optimisation, Ventricular activation time",
author = "Helder Pereira and Jackson, {Tom A.} and Benjamin Sieniewicz and Justin Gould and Cheng Yao and Steven Niederer and Rinaldi, {Christopher A.}",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.jelectrocard.2018.05.006",
language = "English",
volume = "51",
pages = "714--719",
journal = "Journal of Electrocardiology",
issn = "0022-0736",
publisher = "Churchill Livingstone",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Non-invasive electrophysiological assessment of the optimal configuration of quadripolar lead vectors on ventricular activation times

AU - Pereira, Helder

AU - Jackson, Tom A.

AU - Sieniewicz, Benjamin

AU - Gould, Justin

AU - Yao, Cheng

AU - Niederer, Steven

AU - Rinaldi, Christopher A.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background Cardiac resynchronization therapy (CRT) is now generally delivered via quadripolar leads. Assessment of the effect of different vector programs from quadripolar leads on ventricular activation can be now done using non-invasive electrocardiographic mapping (ECM). Material and methods In nineteen patients with quadripolar LV leads, activation maps were constructed. The total ventricular activation time (TVaT) and the time for the bulk of ventricular activation (VaT10–90) were calculated. Results CRT delivered via a quadripolar lead significantly reduced TVaT and VaT10–90 by a mean of 16 ms and 31 ms, respectively, compared to baseline. There was a marked reduction in ventricular activation between the most and least synchronous vectors: 28% difference in baseline TVaT and 37% difference in VaT10–90. Conclusion Changes in the configuration of an LV quadripolar lead significantly affected ventricular activation timings in both ischaemic and non-ischaemic subjects. This suggests that programming of the optimal pacing vector may need to be individually tailored.

AB - Background Cardiac resynchronization therapy (CRT) is now generally delivered via quadripolar leads. Assessment of the effect of different vector programs from quadripolar leads on ventricular activation can be now done using non-invasive electrocardiographic mapping (ECM). Material and methods In nineteen patients with quadripolar LV leads, activation maps were constructed. The total ventricular activation time (TVaT) and the time for the bulk of ventricular activation (VaT10–90) were calculated. Results CRT delivered via a quadripolar lead significantly reduced TVaT and VaT10–90 by a mean of 16 ms and 31 ms, respectively, compared to baseline. There was a marked reduction in ventricular activation between the most and least synchronous vectors: 28% difference in baseline TVaT and 37% difference in VaT10–90. Conclusion Changes in the configuration of an LV quadripolar lead significantly affected ventricular activation timings in both ischaemic and non-ischaemic subjects. This suggests that programming of the optimal pacing vector may need to be individually tailored.

KW - Cardiac resynchronization therapy

KW - Non-invasive electrocardiographic mapping

KW - Quadripolar left ventricular lead

KW - Optimisation

KW - Ventricular activation time

UR - http://www.scopus.com/inward/record.url?scp=85047276691&partnerID=8YFLogxK

U2 - 10.1016/j.jelectrocard.2018.05.006

DO - 10.1016/j.jelectrocard.2018.05.006

M3 - Article

VL - 51

SP - 714

EP - 719

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

SN - 0022-0736

IS - 4

ER -

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