Research output: Contribution to journal › Article › peer-review
David Marlevi, Jonas Schollenberger, Maria Aristova, Edward Ferdian, Yue Ma, Alistair A. Young, Elazer R. Edelman, Susanne Schnell, C. Alberto Figueroa, David A. Nordsletten
Original language | English |
---|---|
Pages (from-to) | 3096-3110 |
Number of pages | 15 |
Journal | Magnetic Resonance in Medicine |
Volume | 86 |
Issue number | 6 |
DOIs | |
Accepted/In press | 2021 |
Published | Dec 2021 |
Additional links |
Purpose: Hemodynamic alterations are indicative of cerebrovascular disease. However, the narrow and tortuous cerebrovasculature complicates image-based assessment, especially when quantifying relative pressure. Here, we present a systematic evaluation of image-based cerebrovascular relative pressure mapping, investigating the accuracy of the routinely used reduced Bernoulli (RB), the extended unsteady Bernoulli (UB), and the full-field virtual work-energy relative pressure ((Formula presented.) WERP) method. Methods: Patient-specific in silico models were used to generate synthetic cerebrovascular 4D Flow MRI, with RB, UB, and (Formula presented.) WERP performance quantified as a function of spatiotemporal sampling and image noise. Cerebrovascular relative pressures were also derived in 4D Flow MRI from healthy volunteers ((Formula presented.)), acquired at two spatial resolutions (dx = 1.1 and 0.8 mm). Results: The in silico analysis indicate that accurate relative pressure estimations are inherently coupled to spatial sampling: at dx = 1.0 mm high errors are reported for all methods; at dx = 0.5 mm (Formula presented.) WERP recovers relative pressures at a mean error of 0.02 ± 0.25 mm Hg, while errors remain higher for RB and UB (mean error of −2.18 ± 1.91 and −2.18 ± 1.87 mm Hg, respectively). The dependence on spatial sampling is also indicated in vivo, albeit with higher correlative dependence between resolutions using (Formula presented.) WERP (k = 0.64, R2 = 0.81 for dx = 1.1 vs. 0.8 mm) than with RB or UB (k = 0.04, R2 = 0.03, and k = 0.07, R2 = 0.07, respectively). Conclusion: Image-based full-field methods such as (Formula presented.) WERP enable cerebrovascular relative pressure mapping; however, accuracy is directly dependent on utilized spatial resolution.
King's College London - Homepage
© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454