Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study

TY - JOUR

T1 - Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study

AU - O'Sullivan, M

AU - Summers, P E

AU - Jones, D K

AU - Jarosz, J M

AU - Williams, S C R

AU - Markus, H S

PY - 2001/12/26

Y1 - 2001/12/26

N2 - Ischemic leukoaraiosis is a consistent concomitant of vascular dementia. Conventional MRI provides little information about underlying white matter tract disruption and correlates poorly with cognitive dysfunction. Diffusion tensor MRI may provide better markers of tract integrity. Changes in the normal-appearing white matter were demonstrated in 30 patients with ischemic leukoaraiosis compared with 17 age-matched control subjects. These changes correlated with executive dysfunction assessed by the Wisconsin Card Sorting Test.

AB - Ischemic leukoaraiosis is a consistent concomitant of vascular dementia. Conventional MRI provides little information about underlying white matter tract disruption and correlates poorly with cognitive dysfunction. Diffusion tensor MRI may provide better markers of tract integrity. Changes in the normal-appearing white matter were demonstrated in 30 patients with ischemic leukoaraiosis compared with 17 age-matched control subjects. These changes correlated with executive dysfunction assessed by the Wisconsin Card Sorting Test.

UR - http://www.scopus.com/inward/record.url?scp=0035956516&partnerID=8YFLogxK

M3 - Article

SN - 1526-632X

VL - 57

SP - 2307

EP - 2310

JO - Neurology

JF - Neurology

IS - 12

ER -