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Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis

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Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis. / O'Neill, Aisling; Wilson, Robin Paul; Blest-Hopley, Grace Elizabeth; Annibale, Luciano; Colizzi, Marco; Brammer, Michael; Giampietro, Vincent Pierre; Bhattacharyya, Sagnik.

In: Psychological medicine, 01.2020.

Research output: Contribution to journalArticle

Harvard

O'Neill, A, Wilson, RP, Blest-Hopley, GE, Annibale, L, Colizzi, M, Brammer, M, Giampietro, VP & Bhattacharyya, S 2020, 'Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis', Psychological medicine. https://doi.org/10.1017/S0033291719003519

APA

O'Neill, A., Wilson, R. P., Blest-Hopley, G. E., Annibale, L., Colizzi, M., Brammer, M., ... Bhattacharyya, S. (2020). Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis. Psychological medicine. https://doi.org/10.1017/S0033291719003519

Vancouver

O'Neill A, Wilson RP, Blest-Hopley GE, Annibale L, Colizzi M, Brammer M et al. Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis. Psychological medicine. 2020 Jan. https://doi.org/10.1017/S0033291719003519

Author

O'Neill, Aisling ; Wilson, Robin Paul ; Blest-Hopley, Grace Elizabeth ; Annibale, Luciano ; Colizzi, Marco ; Brammer, Michael ; Giampietro, Vincent Pierre ; Bhattacharyya, Sagnik. / Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis. In: Psychological medicine. 2020.

Bibtex Download

@article{c5a6b7268e5e4a6e9450cbb27f670df5,
title = "Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis",
abstract = "BackgroundRecent evidence suggests that cannabidiol (CBD), a non-intoxicating ingredient present in cannabis extract, has an antipsychotic effect in people with established psychosis. However, the effect of CBD on the neurocognitive mechanisms underlying psychosis is unknown.MethodsPatients with established psychosis on standard antipsychotic treatment were studied on separate days at least one week apart, to investigate the effects of a single dose of orally administered CBD (600 mg) compared to a matched placebo (PLB), using a double-blind, randomized, PLB-controlled, repeated-measures, within-subject cross-over design. Three hours after taking the study drug participants were scanned using a block design functional magnetic resonance imaging (fMRI) paradigm, while performing a verbal paired associate learning task. Fifteen psychosis patients completed both study days, 13 completed both scanning sessions. Nineteen healthy controls (HC) were also scanned using the same fMRI paradigm under identical conditions, but without any drug administration. Effects of CBD on brain activation measured using the blood oxygen level-dependent hemodynamic response fMRI signal were studied in the mediotemporal, prefrontal, and striatal regions of interest.ResultsCompared to HC, psychosis patients under PLB had altered prefrontal activation during verbal encoding, as well as altered mediotemporal and prefrontal activation and greater mediotemporal-striatal functional connectivity during verbal recall. CBD attenuated dysfunction in these regions such that activation under its influence was intermediate between the PLB condition and HC. CBD also attenuated hippocampal-striatal functional connectivity and caused trend-level symptom reduction in psychosis patients.ConclusionsThis suggests that normalization of mediotemporal and prefrontal dysfunction and mediotemporal-striatal functional connectivity may underlie the antipsychotic effects of CBD.",
keywords = "Cannabidiol, cannabinoid, fMRI, functional connectivity, memory, psychosis, schizophrenia",
author = "Aisling O'Neill and Wilson, {Robin Paul} and Blest-Hopley, {Grace Elizabeth} and Luciano Annibale and Marco Colizzi and Michael Brammer and Giampietro, {Vincent Pierre} and Sagnik Bhattacharyya",
year = "2020",
month = "1",
doi = "10.1017/S0033291719003519",
language = "English",
journal = "Psychological medicine",
issn = "0033-2917",
publisher = "Cambridge University Press (CUP)",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis

AU - O'Neill, Aisling

AU - Wilson, Robin Paul

AU - Blest-Hopley, Grace Elizabeth

AU - Annibale, Luciano

AU - Colizzi, Marco

AU - Brammer, Michael

AU - Giampietro, Vincent Pierre

AU - Bhattacharyya, Sagnik

PY - 2020/1

Y1 - 2020/1

N2 - BackgroundRecent evidence suggests that cannabidiol (CBD), a non-intoxicating ingredient present in cannabis extract, has an antipsychotic effect in people with established psychosis. However, the effect of CBD on the neurocognitive mechanisms underlying psychosis is unknown.MethodsPatients with established psychosis on standard antipsychotic treatment were studied on separate days at least one week apart, to investigate the effects of a single dose of orally administered CBD (600 mg) compared to a matched placebo (PLB), using a double-blind, randomized, PLB-controlled, repeated-measures, within-subject cross-over design. Three hours after taking the study drug participants were scanned using a block design functional magnetic resonance imaging (fMRI) paradigm, while performing a verbal paired associate learning task. Fifteen psychosis patients completed both study days, 13 completed both scanning sessions. Nineteen healthy controls (HC) were also scanned using the same fMRI paradigm under identical conditions, but without any drug administration. Effects of CBD on brain activation measured using the blood oxygen level-dependent hemodynamic response fMRI signal were studied in the mediotemporal, prefrontal, and striatal regions of interest.ResultsCompared to HC, psychosis patients under PLB had altered prefrontal activation during verbal encoding, as well as altered mediotemporal and prefrontal activation and greater mediotemporal-striatal functional connectivity during verbal recall. CBD attenuated dysfunction in these regions such that activation under its influence was intermediate between the PLB condition and HC. CBD also attenuated hippocampal-striatal functional connectivity and caused trend-level symptom reduction in psychosis patients.ConclusionsThis suggests that normalization of mediotemporal and prefrontal dysfunction and mediotemporal-striatal functional connectivity may underlie the antipsychotic effects of CBD.

AB - BackgroundRecent evidence suggests that cannabidiol (CBD), a non-intoxicating ingredient present in cannabis extract, has an antipsychotic effect in people with established psychosis. However, the effect of CBD on the neurocognitive mechanisms underlying psychosis is unknown.MethodsPatients with established psychosis on standard antipsychotic treatment were studied on separate days at least one week apart, to investigate the effects of a single dose of orally administered CBD (600 mg) compared to a matched placebo (PLB), using a double-blind, randomized, PLB-controlled, repeated-measures, within-subject cross-over design. Three hours after taking the study drug participants were scanned using a block design functional magnetic resonance imaging (fMRI) paradigm, while performing a verbal paired associate learning task. Fifteen psychosis patients completed both study days, 13 completed both scanning sessions. Nineteen healthy controls (HC) were also scanned using the same fMRI paradigm under identical conditions, but without any drug administration. Effects of CBD on brain activation measured using the blood oxygen level-dependent hemodynamic response fMRI signal were studied in the mediotemporal, prefrontal, and striatal regions of interest.ResultsCompared to HC, psychosis patients under PLB had altered prefrontal activation during verbal encoding, as well as altered mediotemporal and prefrontal activation and greater mediotemporal-striatal functional connectivity during verbal recall. CBD attenuated dysfunction in these regions such that activation under its influence was intermediate between the PLB condition and HC. CBD also attenuated hippocampal-striatal functional connectivity and caused trend-level symptom reduction in psychosis patients.ConclusionsThis suggests that normalization of mediotemporal and prefrontal dysfunction and mediotemporal-striatal functional connectivity may underlie the antipsychotic effects of CBD.

KW - Cannabidiol

KW - cannabinoid

KW - fMRI

KW - functional connectivity

KW - memory

KW - psychosis

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85078803167&partnerID=8YFLogxK

U2 - 10.1017/S0033291719003519

DO - 10.1017/S0033291719003519

M3 - Article

JO - Psychological medicine

JF - Psychological medicine

SN - 0033-2917

ER -

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