Notch-Rho-cGMP interaction: Common point of convergence in microvascular aging-related disease

Anton J.M. Roks; Caroline Cheng; Catherine M. Shanahan

doi:10.1042/CS20210288

Notch-Rho-cGMP interaction: Common point of convergence in microvascular aging-related disease

Anton J.M. Roks^*, Caroline Cheng, Catherine M. Shanahan

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3-Rho kinase-cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

Original language	English
Pages (from-to)	1209-1212
Number of pages	4
Journal	Clinical Science
Volume	135
Issue number	10
DOIs	https://doi.org/10.1042/CS20210288
Publication status	Published - May 2021

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10.1042/CS20210288

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title = "Notch-Rho-cGMP interaction: Common point of convergence in microvascular aging-related disease",

abstract = "Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3-Rho kinase-cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.",

author = "Roks, {Anton J.M.} and Caroline Cheng and Shanahan, {Catherine M.}",

year = "2021",

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TY - JOUR

T1 - Notch-Rho-cGMP interaction

T2 - Common point of convergence in microvascular aging-related disease

AU - Roks, Anton J.M.

AU - Cheng, Caroline

AU - Shanahan, Catherine M.

PY - 2021/5

Y1 - 2021/5

N2 - Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3-Rho kinase-cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

AB - Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3-Rho kinase-cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

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U2 - 10.1042/CS20210288

DO - 10.1042/CS20210288

M3 - Review article

C2 - 34014259

AN - SCOPUS:85106654053

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VL - 135

SP - 1209

EP - 1212

JO - Clinical Science

JF - Clinical Science

IS - 10

ER -

Notch-Rho-cGMP interaction: Common point of convergence in microvascular aging-related disease

Abstract

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