Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

TY - JOUR

T1 - Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

AU - Brai, Emanuele

AU - Marathe, Swananda

AU - Zentilin, Lorena

AU - Giacca, Mauro

AU - Nimpf, Johannes

AU - Kretz, Robert

AU - Scotti, Alessandra

AU - Alberi, Lavinia

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour discrimination and olfactory learning in rodents are essential for survival. Notch1 expression is enriched in mitral cells of the mouse OB. These principal neurons are responsive to specific input odorants and relay the signal to the olfactory cortex. Olfactory stimulation activates a subset of mitral cells, which show an increase in Notch activity. In Notch1cKOKln mice, the loss of Notch1 in mitral cells affects the magnitude of the neuronal response to olfactory stimuli. In addition, Notch1cKOKln mice display reduced olfactory aversion to propionic acid as compared to wildtype controls. This indicates, for the first time, that Notch1 is involved in olfactory processing and may contribute to olfactory behaviour. In this paper we show that Notch1 expression is enriched in mitral cells of the mouse olfactory bulb. Olfactory stimulation can induce Notch pathway activation in mitral cells and their processes. Loss of function of Notch1 in mitral cells, in Notch1cKOKln mice, affects spontaneous and the odor-evoked activity of these cells through cell autonomous and non-cell autonomous mechanisms. Notch1cKOKln mice display normal olfactory preference but impaired olfactory avoidance.

AB - Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour discrimination and olfactory learning in rodents are essential for survival. Notch1 expression is enriched in mitral cells of the mouse OB. These principal neurons are responsive to specific input odorants and relay the signal to the olfactory cortex. Olfactory stimulation activates a subset of mitral cells, which show an increase in Notch activity. In Notch1cKOKln mice, the loss of Notch1 in mitral cells affects the magnitude of the neuronal response to olfactory stimuli. In addition, Notch1cKOKln mice display reduced olfactory aversion to propionic acid as compared to wildtype controls. This indicates, for the first time, that Notch1 is involved in olfactory processing and may contribute to olfactory behaviour. In this paper we show that Notch1 expression is enriched in mitral cells of the mouse olfactory bulb. Olfactory stimulation can induce Notch pathway activation in mitral cells and their processes. Loss of function of Notch1 in mitral cells, in Notch1cKOKln mice, affects spontaneous and the odor-evoked activity of these cells through cell autonomous and non-cell autonomous mechanisms. Notch1cKOKln mice display normal olfactory preference but impaired olfactory avoidance.

KW - Mitral cells

KW - Neuronal activity

KW - Notch1

KW - Olfactory avoidance

KW - Olfactory bulb

UR - http://www.scopus.com/inward/record.url?scp=84916918378&partnerID=8YFLogxK

U2 - 10.1111/ejn.12719

DO - 10.1111/ejn.12719

M3 - Article

C2 - 25234246

AN - SCOPUS:84916918378

SN - 0953-816X

VL - 40

SP - 3436

EP - 3449

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

IS - 10

ER -